{"id":"W2042111313","doi":"10.3109/00498254.2011.611546","title":"Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor","year":2011,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Hepatitis C virus research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Pharmacokinetics; Genotype; Metabolism; Protease inhibitor (pharmacology); Distribution (mathematics); Pharmacology; Absorption (acoustics); NS3; Biology; Chemistry; Protease; Biochemistry; Virology; Enzyme; Virus; Mathematics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003818996,0.0003036987,0.0004784017,0.000259097,0.0001993604,0.0003550343,0.0001358508,0.0002487447,0.0009110325],"category_scores_gemma":[0.0005496552,0.0001607128,0.0003036075,0.0002212552,0.0002512409,0.0003265382,0.0002072322,0.000526729,0.0002771103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005307515,"about_ca_system_score_gemma":0.0003506255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001589481,"about_ca_topic_score_gemma":0.001583353,"domain_scores_codex":[0.999801,0.00007265462,0.000009584846,0.00004035579,0.0000457284,0.00003076725],"domain_scores_gemma":[0.9998245,0.00004482523,0.00006261085,0.00001890159,0.00001697675,0.00003236754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007295525,0.0005012738,0.004763513,0.0001705334,0.0001742152,0.0002563933,0.0002106473,0.001997841,0.9194238,0.0003316518,0.0004842906,0.06439019],"study_design_scores_gemma":[0.0002664466,0.04358917,0.1146999,0.00002955855,0.0006098403,0.004367833,0.0002004956,0.02142011,0.8021083,0.0003881782,0.01221974,0.000100455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922141,0.003407392,0.003143684,0.00004637737,0.00001335136,0.00004780594,0.0001809578,0.00006823751,0.0008780001],"genre_scores_gemma":[0.9956155,0.001337212,0.00163409,0.000069649,0.00001557643,0.00003138132,0.0003929107,0.00002569354,0.0008779996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001589481,"threshold_uncertainty_score":0.003850877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04903577804785964,"score_gpt":0.3147580060088771,"score_spread":0.2657222279610175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}