{"id":"W2042111313","doi":"10.3109/00498254.2011.611546","title":"Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor","year":2011,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Hepatitis C virus research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Pharmacokinetics; Genotype; Metabolism; Protease inhibitor (pharmacology); Distribution (mathematics); Pharmacology; Absorption (acoustics); NS3; Biology; Chemistry; Protease; Biochemistry; Virology; Enzyme; Virus; Mathematics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003363725,0.0001859828,0.0003470263,0.0001204407,0.00009371597,0.000032248,0.000115561,0.0001430925,0.001211414],"category_scores_gemma":[0.0003629858,0.0001581707,0.00007995937,0.0002744331,0.0004808206,0.0001125973,0.0001301848,0.0002945852,0.0001419116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006708682,"about_ca_system_score_gemma":0.0001514782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002191724,"about_ca_topic_score_gemma":0.000009027406,"domain_scores_codex":[0.9983143,0.00008062128,0.0004250406,0.0003192077,0.0004765915,0.0003841979],"domain_scores_gemma":[0.9986419,0.0000345605,0.0001065386,0.0003508145,0.000549891,0.0003163029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003214654,0.002562562,0.1898196,0.001740288,0.0005885491,0.0002336486,0.002645669,0.00000641076,0.7409582,0.007390869,0.0117813,0.03905824],"study_design_scores_gemma":[0.002420159,0.0004751605,0.5782877,0.0001122472,0.0002056012,0.00002197928,0.00004552358,0.0003279952,0.3459236,0.0001450071,0.07178389,0.0002512104],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99183,0.0009433005,0.0008074336,0.0005724027,0.0001974254,0.001199163,0.000468189,0.00007344241,0.003908645],"genre_scores_gemma":[0.9967209,0.0007375001,0.001032401,0.00008880344,0.0002437409,0.00002595623,0.0001133852,0.0000308184,0.001006499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3950346,"threshold_uncertainty_score":0.9997016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04903577804785964,"score_gpt":0.3147580060088771,"score_spread":0.2657222279610175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}