{"id":"W2042113382","doi":"10.1242/jcs.110262","title":"Intrinsic directionality of migrating vascular smooth muscle cells is regulated by NAD+ biosynthesis","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University; Robarts Clinical Trials","funders":"Canadian Institutes of Health Research","keywords":"Lamellipodium; Cell biology; Biology; Motility; Pseudopodia; Nicotinamide phosphoribosyltransferase; Cell migration; NAD+ kinase; Filopodia; Cell; Biochemistry; Actin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001320095,0.00009577793,0.0001413537,0.00006148286,0.00009430999,0.00001981763,0.0003600029,0.00006250062,0.00004658621],"category_scores_gemma":[0.0002505196,0.00008127915,0.0001481581,0.0002862592,0.0002783771,0.00002267586,0.00007338324,0.00007846676,0.000002381822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003137772,"about_ca_system_score_gemma":0.0001889799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000136375,"about_ca_topic_score_gemma":6.046012e-7,"domain_scores_codex":[0.9987332,0.00006665955,0.0003333534,0.0001583167,0.0004694418,0.0002390859],"domain_scores_gemma":[0.9988121,0.00003094749,0.0004053081,0.0002397328,0.0003096878,0.0002022498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001892122,0.0001396898,0.001617961,0.00001329058,0.00001191437,5.408737e-7,0.0000842156,0.00002669115,0.9950575,0.00000224971,0.001632906,0.001394127],"study_design_scores_gemma":[0.0001729513,0.00009037348,0.007389744,0.0000216367,0.00002709269,0.00000261423,0.00004977918,0.0000171302,0.9840686,0.0000161324,0.008051903,0.00009200832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973035,0.001672866,0.000315635,0.00004775023,0.0002887585,0.00004322905,0.00001232392,0.000002819652,0.0003130559],"genre_scores_gemma":[0.998007,0.00005634908,0.001636493,0.00009591888,0.0001450617,5.907795e-7,0.000001102567,0.000007797065,0.00004970101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01098886,"threshold_uncertainty_score":0.3314467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008005195257172868,"score_gpt":0.2304765296885896,"score_spread":0.2224713344314168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}