{"id":"W2042128990","doi":"10.1016/j.cell.2007.06.050","title":"Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"Deutsche Forschungsgemeinschaft; Howard Hughes Medical Institute","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; NEDD4; Biology; Cell biology; Signal transducing adaptor protein; WW domain; Plasma protein binding; Cysteine; Signal transduction; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001664212,0.0003490963,0.0001991469,0.0001384043,0.0002112489,0.0003681736,0.0002618016,0.0003052933,0.001670152],"category_scores_gemma":[0.0001297497,0.0001309856,0.0001746514,0.0001145515,0.0001903848,0.0002371961,0.0002177744,0.0003284521,0.0005100607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005206887,"about_ca_system_score_gemma":0.0002250103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009961464,"about_ca_topic_score_gemma":0.001440334,"domain_scores_codex":[0.9998969,0.00001416811,0.000004033324,0.00001575463,0.00002615014,0.00004298239],"domain_scores_gemma":[0.9999329,0.00001229555,0.00001519093,0.00001079219,0.000009285969,0.00001960889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00031128,0.00002922367,0.0003228929,0.00003653146,0.000009626627,0.0001817496,0.000008034807,0.0001792399,0.9955089,0.0006052156,0.0003701931,0.00243717],"study_design_scores_gemma":[0.00004155584,0.00008599983,0.00449454,0.00000320064,0.000007978217,0.0005842648,0.00001980971,0.002714286,0.9883174,0.0001486665,0.003575165,0.000007088162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921111,0.002272505,0.001450646,0.0001701318,0.00002993795,0.000007139894,0.0001311326,0.0001005285,0.003726913],"genre_scores_gemma":[0.9968965,0.0003121101,0.0002921445,0.00003928065,0.000007956812,0.000004774276,0.0001371473,0.000009810315,0.002300258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001670152,"threshold_uncertainty_score":0.00558722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401528919748011,"score_gpt":0.245067301166622,"score_spread":0.2310520119691419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}