{"id":"W2042128990","doi":"10.1016/j.cell.2007.06.050","title":"Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"Deutsche Forschungsgemeinschaft; Howard Hughes Medical Institute","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; NEDD4; Biology; Cell biology; Signal transducing adaptor protein; WW domain; Plasma protein binding; Cysteine; Signal transduction; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002795725,0.0001160959,0.00009965203,0.00001456613,0.00007664103,0.000008273526,0.0001741546,0.0001481749,0.0000740326],"category_scores_gemma":[0.00004589543,0.0000907736,0.00009792927,0.0001188921,0.00006925307,0.000003030561,0.0001090549,0.0000971382,0.00004027432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001042216,"about_ca_system_score_gemma":0.00006221594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009200728,"about_ca_topic_score_gemma":0.00001584302,"domain_scores_codex":[0.9991818,0.0000540236,0.0001989555,0.0002095647,0.0001224723,0.0002331492],"domain_scores_gemma":[0.9994314,0.00001402927,0.0001069302,0.0003192706,0.00008223419,0.00004615308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005543636,0.00005946518,0.0001220831,0.00004103328,0.00000633659,0.000002815227,0.0001574926,0.000004692517,0.9969451,0.0003253605,0.002049343,0.0002308824],"study_design_scores_gemma":[0.000335671,0.0001741826,0.0003049959,0.00002207156,0.000007622568,0.000008365439,0.00008628952,0.000002746836,0.9424212,0.0004850913,0.05604271,0.0001090763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575369,0.0008502395,0.0005063021,0.0001098811,0.0002358223,0.00022615,0.00001926905,0.00001314553,0.04050234],"genre_scores_gemma":[0.9965738,0.00006320471,0.0006777135,0.0004893864,0.0002251825,0.000004521681,0.00003994448,0.00001823946,0.001907992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05452389,"threshold_uncertainty_score":0.370164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401528919748011,"score_gpt":0.245067301166622,"score_spread":0.2310520119691419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}