{"id":"W2042129455","doi":"10.1124/jpet.106.114678","title":"Inhibition of Acrolein-Induced Apoptosis by the Antioxidant N-Acetylcysteine","year":2007,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Acrolein; Acetylcysteine; Apoptosis; Glutathione; Cytochrome c; Mitochondrion; Cytosol; Programmed cell death; Molecular biology; Biochemistry; Chemistry; Intracellular; Antioxidant; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004858735,0.00008896781,0.0001637204,0.00001119595,0.0001141888,0.00000945855,0.0001009533,0.00007276433,0.0001020119],"category_scores_gemma":[0.000002855938,0.0000311562,0.00007021297,0.0001039469,0.0001095131,0.00008241105,0.00002935472,0.0001514381,8.585297e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001808466,"about_ca_system_score_gemma":0.000006775583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001267552,"about_ca_topic_score_gemma":0.000003745568,"domain_scores_codex":[0.9992433,0.00007656036,0.0003263371,0.00007029394,0.0001336672,0.0001498638],"domain_scores_gemma":[0.9994506,0.0001564307,0.000272879,0.00001661315,0.00005656529,0.00004687129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002711882,0.0002286928,0.0003858338,0.000001449626,0.00006718794,0.000003268069,0.0002298844,4.145637e-7,0.9915562,0.00003249194,0.0004139269,0.006809451],"study_design_scores_gemma":[0.0005315233,0.001121413,0.002456021,0.00000610195,0.00004412364,0.00006209117,0.0007398713,0.000007015574,0.9925539,0.00004914289,0.002367336,0.00006141116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967443,0.001696871,0.0000205653,0.001075075,0.0002589616,0.00007090828,0.00000614215,0.000004533413,0.0001225804],"genre_scores_gemma":[0.9981008,0.0001493448,0.00003153895,0.001462507,0.00023656,8.504962e-7,0.000001350557,8.149561e-7,0.00001627843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00674804,"threshold_uncertainty_score":0.1270513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755040941944088,"score_gpt":0.3069773343389305,"score_spread":0.2794269249194896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}