{"id":"W2042144124","doi":"10.1074/jbc.m608247200","title":"Stored Ca2+ Depletion-induced Oligomerization of Stromal Interaction Molecule 1 (STIM1) via the EF-SAM Region","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":405,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"STIM1; Chemistry; Oligomer; Endoplasmic reticulum; Membrane; Biophysics; Dimer; Crystallography; Molecule; Monomer; Dissociation constant; Cytoplasm; Stereochemistry; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007263908,0.0002007801,0.0001252775,0.00007107468,0.0001137924,0.0001369083,0.00007914755,0.000123216,0.0008377651],"category_scores_gemma":[0.0001019873,0.00004964522,0.0001626736,0.00006192033,0.0001187535,0.0001565965,0.0001455379,0.0001844214,0.0002691025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547778,"about_ca_system_score_gemma":0.00006155262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001722241,"about_ca_topic_score_gemma":0.0002553521,"domain_scores_codex":[0.9999589,0.000006890955,0.000003009726,0.00001169856,0.00000925839,0.00001022692],"domain_scores_gemma":[0.9999415,0.00001096518,0.00002249536,0.000006794945,0.000006742195,0.00001139136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005729447,0.000005144865,0.0003582785,0.00001527495,0.000003195403,0.00003775988,0.00001337604,0.00003353981,0.9987704,0.00004802588,0.00002324385,0.0006343544],"study_design_scores_gemma":[0.000007580244,0.0001190707,0.01808869,0.000004889419,0.000008391005,0.0004547828,0.00003282891,0.001243612,0.9774301,0.00009312552,0.002512686,0.000004320629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978302,0.0005391492,0.001094721,0.00003766376,0.00000544015,0.000004728613,0.0001068023,0.00002162773,0.0003596275],"genre_scores_gemma":[0.9972006,0.0002877905,0.00104447,0.00003528947,0.000006196605,0.0000100927,0.0004222167,0.000008204542,0.0009850884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008377651,"threshold_uncertainty_score":0.00280261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03639906450368269,"score_gpt":0.2632000318223829,"score_spread":0.2268009673187002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}