{"id":"W2042148986","doi":"10.1210/jc.2010-1899","title":"Inhibition of the Ras/Raf/MEK/ERK and RET Kinase Pathways with the Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Medullary and Differentiated Thyroid Malignancies","year":2011,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Bayer Canada","keywords":"Sorafenib; Medicine; Medullary thyroid cancer; Internal medicine; Farnesyltransferase inhibitor; Thyroid cancer; MEK inhibitor; Rash; Oncology; Endocrinology; MAPK/ERK pathway; Cancer; Cancer research; Farnesyltransferase; Kinase; Prenylation; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005038744,0.0003572323,0.0006059013,0.0002126129,0.0001687488,0.0002959433,0.0002815685,0.0001894477,0.0007803463],"category_scores_gemma":[0.0002596853,0.0001658212,0.000383374,0.0002308747,0.0002549597,0.0001983184,0.0002231343,0.0005724592,0.0001378206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005701809,"about_ca_system_score_gemma":0.0005846546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008144927,"about_ca_topic_score_gemma":0.003603151,"domain_scores_codex":[0.999811,0.00004855136,0.00001899334,0.00003028922,0.00004273245,0.00004842531],"domain_scores_gemma":[0.9998511,0.00002669127,0.00003270982,0.00000961842,0.0000150079,0.00006490568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04834574,0.005914133,0.08581968,0.001374441,0.001360433,0.001117683,0.0003506751,0.006819855,0.5036618,0.0004162444,0.002050157,0.3427691],"study_design_scores_gemma":[0.04248217,0.2815802,0.29806,0.0001775594,0.002585626,0.01184677,0.0003979902,0.01693566,0.321143,0.0004408485,0.02425007,0.0001001106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951594,0.003861782,0.0001894769,0.0000744493,0.00001088621,0.00005320926,0.0000459001,0.00001606639,0.0005888198],"genre_scores_gemma":[0.9985062,0.0007312691,0.0003787681,0.00003397524,0.00001346253,0.0000310707,0.0001068031,0.000002095326,0.0001963167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008144927,"threshold_uncertainty_score":0.00413698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03075839530382419,"score_gpt":0.2695380579720285,"score_spread":0.2387796626682043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}