{"id":"W2042168553","doi":"10.1371/journal.pone.0012856","title":"Hepatitis C Virus Core Protein Induces Neuroimmune Activation and Potentiates Human Immunodeficiency Virus-1 Neurotoxicity","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis C virus research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Montreal Clinical Research Institute; Université de Montréal; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Microglia; Hepatitis C virus; Neurotoxicity; Biology; Virology; Neuroinflammation; Astrocyte; Antiviral protein; Chemokine; CXCL10; Tumor necrosis factor alpha; Immune system; Immunology; Virus; Chemistry; Inflammation; Central nervous system; RNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003577095,0.0002348812,0.0004043481,0.000259275,0.0003563353,0.0001009718,0.0002077022,0.0001813367,0.0004283253],"category_scores_gemma":[0.001031796,0.0002276931,0.00005705698,0.0003604432,0.0002602159,0.0003220633,0.0001873112,0.001107712,0.0001060074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004880257,"about_ca_system_score_gemma":0.0001174282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005502206,"about_ca_topic_score_gemma":0.0006912891,"domain_scores_codex":[0.9975789,0.00009019711,0.000390967,0.0004688483,0.001025893,0.0004452194],"domain_scores_gemma":[0.9987631,0.00006326954,0.0001395345,0.0004990211,0.0003535663,0.0001815276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007183188,0.001581714,0.04638474,0.0001547359,0.00006759704,0.00002735265,0.0001343483,8.926516e-8,0.9497007,0.0001477618,0.00002718417,0.001701937],"study_design_scores_gemma":[0.0006023415,0.0005226588,0.2698864,0.0001701703,0.0000382722,0.000005554642,0.000006115467,0.0002063666,0.7280899,0.0002164404,0.00009290939,0.0001628384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950867,0.00005370497,0.000007793583,0.0004492736,0.00003407886,0.001703715,0.00004184656,0.0001609735,0.002461949],"genre_scores_gemma":[0.9981275,0.0002565809,0.0004865497,0.000246874,0.0001202187,0.0002093386,0.00004780487,0.0000610369,0.00044406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2235017,"threshold_uncertainty_score":0.9285055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08177308406002577,"score_gpt":0.3005257754704497,"score_spread":0.218752691410424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}