{"id":"W2042173490","doi":"10.1016/s0092-8674(03)00345-3","title":"The Zipper Model of Translational Control","year":2003,"lang":"en","type":"article","venue":"Cell","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Internal ribosome entry site; Biology; Translation (biology); Upstream open reading frame; Messenger RNA; Cell biology; Protein biosynthesis; Five prime untranslated region; Open reading frame; Ribosome; RNA; Translational regulation; Eukaryotic translation; Eukaryotic initiation factor; Transfer RNA; Amino acid; Molecular biology; Genetics; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000455914,0.00002867717,0.0000248335,0.000003703011,0.00003078177,0.000003298064,0.00003459289,0.00002494679,0.00001908949],"category_scores_gemma":[0.00001040163,0.00002031241,0.00003920719,0.00001088442,0.00002918131,5.356132e-7,0.000001741342,0.00001036997,0.00000327649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":6.868781e-7,"about_ca_system_score_gemma":0.000040984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.187455e-7,"about_ca_topic_score_gemma":7.494002e-7,"domain_scores_codex":[0.9997804,0.00001634572,0.00005873334,0.00005326479,0.00004277846,0.00004846803],"domain_scores_gemma":[0.9998335,0.000005273598,0.00001761774,0.00009174295,0.00002688991,0.00002501834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005664221,0.00004126684,0.00193509,0.000004470381,0.000009360471,7.82737e-8,0.0000134438,0.01426737,0.9771213,0.004142078,0.002169502,0.0002393975],"study_design_scores_gemma":[0.003487198,0.00006969835,0.005260019,0.000002372484,0.00003500687,0.000001385919,0.00004970608,0.04176366,0.8338895,0.003982356,0.1112527,0.0002063246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956932,0.001800413,0.04146172,0.0003008956,0.00006766863,0.0001361179,0.00002594609,0.000004172419,0.06050982],"genre_scores_gemma":[0.9965799,0.00001751932,0.0001659211,0.0001291763,0.00001272364,0.000002707661,0.000008300772,0.000003155855,0.003080616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1432318,"threshold_uncertainty_score":0.0828316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007150524121598392,"score_gpt":0.2128821131561718,"score_spread":0.2057315890345734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}