{"id":"W2042183771","doi":"10.1038/mtm.2013.5","title":"Targeted CNS delivery using human MiniPromoters and demonstrated compatibility with adeno-associated viral vectors","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Child and Family Research Institute; University of British Columbia","funders":"National Institute of General Medical Sciences; National Eye Institute; National Institutes of Health; Genome British Columbia; Research to Prevent Blindness; Child and Family Research Institute; Michael Smith Health Research BC; Macula Vision Research Foundation; GlaxoSmithKline; Canadian Institutes of Health Research; Genome Canada","keywords":"Biology; Adeno-associated virus; Gene; Gene expression; Reporter gene; Viral vector; Genetic enhancement; Vectors in gene therapy; Locus (genetics); Genetics; Neuroscience; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001877004,0.0003264578,0.0004322016,0.00005331768,0.0001594035,0.00003985599,0.000192026,0.0002752884,0.00001097791],"category_scores_gemma":[0.0001891495,0.0002871806,0.0001156221,0.0001349446,0.0001811184,0.00000446535,0.00009963718,0.000223749,0.000001093118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003234198,"about_ca_system_score_gemma":0.0001295874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002837644,"about_ca_topic_score_gemma":0.0000239848,"domain_scores_codex":[0.9971836,0.0009170384,0.0006497106,0.0006761853,0.0001899572,0.0003835586],"domain_scores_gemma":[0.9990486,0.00008801197,0.0001600117,0.0003740442,0.0001215907,0.0002077697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140782,0.0001850601,0.02162269,0.0000130338,0.0004724556,0.000006255551,0.0001093246,0.0002963259,0.9284884,0.000008236935,0.00001024276,0.04864715],"study_design_scores_gemma":[0.002682258,0.001056696,0.175916,0.00005247277,0.00007007731,0.00001029448,0.00004371721,0.002217612,0.8140196,0.00009257065,0.003129339,0.0007093519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7481841,0.0004681721,0.2509229,0.00002095226,0.00009535076,0.0002391083,0.000002198218,0.00002913898,0.00003802162],"genre_scores_gemma":[0.74525,0.00004663358,0.2542899,0.0002407775,0.00003334966,0.00001078032,0.00007084854,0.00003816352,0.00001954818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1542933,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04121332399426751,"score_gpt":0.4150032049627303,"score_spread":0.3737898809684628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}