{"id":"W2042191064","doi":"10.2174/187152612800100161","title":"Prion Disease: Chemotherapeutic Strategies","year":2012,"lang":"en","type":"review","venue":"Infectious Disorders - Drug Targets","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chronic wasting disease; Bovine spongiform encephalopathy; Disease; Neurodegeneration; Transmissible spongiform encephalopathy; Prion protein; Biology; Virology; In vivo; Pathogenesis; Medicine; Neuroscience; Scrapie; Immunology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001984255,0.000665693,0.0007448402,0.0001266721,0.0002147587,0.0001219035,0.000370616,0.000346279,0.0002086911],"category_scores_gemma":[0.0000393436,0.0006087308,0.0008220333,0.0001850112,0.0001053809,0.00001728561,0.0001907736,0.0002848157,0.0001335655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005898076,"about_ca_system_score_gemma":0.0004895603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004319111,"about_ca_topic_score_gemma":0.00006614441,"domain_scores_codex":[0.9978412,0.0002191749,0.0004407583,0.0006668482,0.0002108104,0.0006212088],"domain_scores_gemma":[0.998602,0.00002598312,0.0003258108,0.0006848366,0.00004522133,0.00031617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001473612,0.0001855087,0.00009230537,0.003958708,0.0003119186,0.000001434379,0.00002351493,0.000008455951,0.00001556484,0.00007856476,0.0009643573,0.9943449],"study_design_scores_gemma":[0.0002428517,0.00004412864,0.00003125946,0.0006581277,0.000663109,0.00000788233,0.00001412688,0.000002373588,0.00001803084,0.0004712624,0.9971126,0.0007342998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007094287,0.9967352,0.0005176698,0.00003792977,0.0005233686,0.001041676,0.00006953908,0.0001009353,0.0009027819],"genre_scores_gemma":[0.00537686,0.992278,0.00003190874,0.0001384269,0.0006274226,0.0003363639,0.0007787686,0.0001505655,0.0002816775],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9961482,"threshold_uncertainty_score":0.9996364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492679580410892,"score_gpt":0.2964559447072792,"score_spread":0.2815291489031702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}