{"id":"W2042191064","doi":"10.2174/187152612800100161","title":"Prion Disease: Chemotherapeutic Strategies","year":2012,"lang":"en","type":"review","venue":"Infectious Disorders - Drug Targets","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chronic wasting disease; Bovine spongiform encephalopathy; Disease; Neurodegeneration; Transmissible spongiform encephalopathy; Prion protein; Biology; Virology; In vivo; Pathogenesis; Medicine; Neuroscience; Scrapie; Immunology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004948914,0.0007354649,0.0006109215,0.001214948,0.0005769237,0.001151272,0.0005939753,0.0009746026,0.006649876],"category_scores_gemma":[0.0005579415,0.0002536887,0.0005019034,0.000773208,0.0005809496,0.001002591,0.0009407305,0.002284065,0.0029652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00129076,"about_ca_system_score_gemma":0.000574344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120934,"about_ca_topic_score_gemma":0.002125855,"domain_scores_codex":[0.9997213,0.00005362908,0.00001632177,0.00006075226,0.0001044294,0.00004349224],"domain_scores_gemma":[0.99978,0.00004823042,0.00003669048,0.00002201135,0.00007265269,0.00004034994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005211092,0.0008430629,0.001147506,0.00499585,0.0001856323,0.00172491,0.0004289085,0.002796612,0.08705673,0.03936035,0.06711657,0.7938227],"study_design_scores_gemma":[0.0001388656,0.0008502869,0.001361945,0.0008857037,0.0001173042,0.003746163,0.0001020187,0.001352418,0.02880196,0.01382618,0.9487488,0.00006836683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0257957,0.8479694,0.02253945,0.01687209,0.003380735,0.0004563882,0.0006517812,0.0005475896,0.08178685],"genre_scores_gemma":[0.1902999,0.7180845,0.01577794,0.0113069,0.002520052,0.0005933158,0.001060959,0.0001348723,0.06022171],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006649876,"threshold_uncertainty_score":0.02224606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492679580410892,"score_gpt":0.2964559447072792,"score_spread":0.2815291489031702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}