{"id":"W2042223874","doi":"10.1021/jm201091t","title":"Discovery of a Novel Class of Orally Active Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Office of Naval Research; Wellcome Trust","keywords":"Chemistry; Trypanocidal agent; Orally active; Pharmacology; Structure–activity relationship; Stereochemistry; Biochemistry; In vitro; Trypanosoma brucei","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379046,0.0004351518,0.0005786003,0.0002327905,0.0001434943,0.0003572152,0.0004278469,0.0003291533,0.001512188],"category_scores_gemma":[0.0001162502,0.0001490714,0.0002221959,0.0001930382,0.0001875356,0.0002454626,0.0002731911,0.0005357537,0.000490544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407358,"about_ca_system_score_gemma":0.0002442393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002717449,"about_ca_topic_score_gemma":0.0008566374,"domain_scores_codex":[0.9999415,0.00000647741,0.000004869187,0.00001409892,0.00001362588,0.00001947198],"domain_scores_gemma":[0.9999534,0.000004523054,0.00001257621,0.00000401572,0.00000811902,0.00001731121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005539445,0.0003919246,0.0005355678,0.0001973286,0.00002887222,0.0005309586,0.00005010591,0.001376115,0.946109,0.0009585786,0.00122148,0.04804615],"study_design_scores_gemma":[0.001373128,0.01184103,0.004565071,0.00006264262,0.0001460181,0.003026843,0.00005157827,0.003612235,0.9241151,0.0006200531,0.0505355,0.00005098407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525011,0.01333534,0.01799134,0.0009639621,0.000198672,0.0005863085,0.001773594,0.0005860084,0.01206385],"genre_scores_gemma":[0.9645554,0.01033389,0.01462481,0.0005619731,0.00009343174,0.0001879818,0.002524451,0.00003844515,0.007079523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512188,"threshold_uncertainty_score":0.005058825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03756309962173521,"score_gpt":0.2923862836999951,"score_spread":0.2548231840782599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}