{"id":"W2042223874","doi":"10.1021/jm201091t","title":"Discovery of a Novel Class of Orally Active Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Office of Naval Research; Wellcome Trust","keywords":"Chemistry; Trypanocidal agent; Orally active; Pharmacology; Structure–activity relationship; Stereochemistry; Biochemistry; In vitro; Trypanosoma brucei","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009691179,0.0001592275,0.0006111285,0.000116285,0.00002838568,0.000004427987,0.0002501602,0.0001372438,0.0002320761],"category_scores_gemma":[0.000493772,0.0001183865,0.0003095685,0.0002819967,0.0004607824,0.0002064553,0.00003293089,0.0006186794,8.881803e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108717,"about_ca_system_score_gemma":0.0008626719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004537791,"about_ca_topic_score_gemma":0.000002320065,"domain_scores_codex":[0.9978034,0.00001888358,0.0008930184,0.0001421035,0.0009014882,0.0002411343],"domain_scores_gemma":[0.9980407,0.000110247,0.0005635567,0.0002813955,0.000696538,0.0003075406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002402439,0.00101048,0.001475102,0.0004441213,0.0002326299,0.00007591117,0.0006598994,5.137955e-7,0.9906482,0.00004550385,0.001643267,0.001361953],"study_design_scores_gemma":[0.003851712,0.001092127,0.04208012,0.0006172017,0.0002098245,0.001089009,0.001847975,0.000005749653,0.948406,0.00005589181,0.000652364,0.00009207634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867116,0.0003812998,0.001117145,0.0007497048,0.00009108195,0.0001231905,0.00006954429,0.000005705253,0.01075077],"genre_scores_gemma":[0.9977646,0.000168165,0.00122056,0.00007493109,0.0003979122,0.000002934881,0.00000803309,0.00001751381,0.0003453629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04224223,"threshold_uncertainty_score":0.4827661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03756309962173521,"score_gpt":0.2923862836999951,"score_spread":0.2548231840782599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}