{"id":"W2042243678","doi":"10.1016/j.bmc.2010.03.078","title":"Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Chemistry; Histone deacetylase; Agonist; Bifunctional; Histone deacetylase inhibitor; In vivo; In vitro; Biochemistry; Pharmacology; Calcitriol receptor; Receptor; Histone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000594647,0.0005246376,0.0004114107,0.00007364128,0.0002403668,0.00005171661,0.000765715,0.000654021,0.001354308],"category_scores_gemma":[0.00100429,0.0005386016,0.0002361609,0.0003363774,0.0007579004,0.0000103348,0.0003406845,0.001075844,0.0003621363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396455,"about_ca_system_score_gemma":0.0007157473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004843946,"about_ca_topic_score_gemma":0.00002066731,"domain_scores_codex":[0.9966,0.00007184254,0.0005722403,0.001071849,0.0008276213,0.0008564742],"domain_scores_gemma":[0.9974757,0.00003258193,0.0001835473,0.001288421,0.0002930516,0.0007266664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001293813,0.000197374,0.00006853823,0.0001059661,0.0000577647,0.0001069775,0.00004498982,3.904949e-7,0.9595381,0.00001360658,0.0384508,0.00128612],"study_design_scores_gemma":[0.001147393,0.0001663808,0.00005505574,0.00004115007,0.00003644748,0.0003248924,0.0001029144,0.000008628807,0.8751078,0.000007973145,0.1224926,0.0005088029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922885,0.000961313,0.0002427721,0.0008748162,0.0008335695,0.0002811521,0.0000806159,0.00009582177,0.004341426],"genre_scores_gemma":[0.9887767,0.00007941653,0.0008969709,0.0003515113,0.002545308,0.00006060905,0.0005958481,0.0001394565,0.006554137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08443035,"threshold_uncertainty_score":0.9997066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005512055495734979,"score_gpt":0.2644927483046365,"score_spread":0.2589806928089016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}