{"id":"W2042243678","doi":"10.1016/j.bmc.2010.03.078","title":"Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Chemistry; Histone deacetylase; Agonist; Bifunctional; Histone deacetylase inhibitor; In vivo; In vitro; Biochemistry; Pharmacology; Calcitriol receptor; Receptor; Histone; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558427,0.0002829903,0.0001916298,0.0002828039,0.0002302304,0.0004594018,0.0006403759,0.000407768,0.005576892],"category_scores_gemma":[0.0001206123,0.0002380207,0.0001912241,0.0001860181,0.000120776,0.0003814092,0.000293842,0.0004938784,0.001523486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003313323,"about_ca_system_score_gemma":0.0001440413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00024556,"about_ca_topic_score_gemma":0.0004432436,"domain_scores_codex":[0.9999001,0.00001395414,0.000005669915,0.00002598558,0.00002393499,0.00003029709],"domain_scores_gemma":[0.9999596,0.00001080389,0.000009897974,0.000005374798,0.00000465426,0.000009728958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005720688,0.0002605823,0.0002768002,0.0002139662,0.00008570217,0.0002164384,0.00007540661,0.002067207,0.9641621,0.01165066,0.001682142,0.01873693],"study_design_scores_gemma":[0.000112774,0.0009444886,0.0004780662,0.000008442237,0.00006369555,0.000221558,0.00003179978,0.001994727,0.9684231,0.0006993013,0.02699795,0.00002401144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8853801,0.004897816,0.046906,0.001157242,0.0006429287,0.0004058057,0.001283942,0.001321038,0.05800517],"genre_scores_gemma":[0.9724262,0.001045198,0.01118663,0.0003547197,0.00004204848,0.0002401055,0.0004793599,0.00004790054,0.01417782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005576892,"threshold_uncertainty_score":0.01865649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005512055495734979,"score_gpt":0.2644927483046365,"score_spread":0.2589806928089016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}