{"id":"W2042283337","doi":"10.1615/critrevimmunol.v30.i5.40","title":"A CCL2-Based Fusokine as a Novel Biopharmaceutical for the Treatment of CCR2-Driven Autoimmune Diseases","year":2010,"lang":"en","type":"review","venue":"Critical Reviews in Immunology","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute; Canadian Institutes of Health Research; Health Research Foundation","keywords":"CCR2; Homing (biology); Chemokine; CCL2; Chemokine receptor; Immunology; CCR1; Monocyte; Immune system; Inflammation; CC chemokine receptors; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004251605,0.0009613136,0.0009170369,0.001270215,0.0002053279,0.0005393801,0.0006535738,0.0009762192,0.001758468],"category_scores_gemma":[0.0002037393,0.0002374817,0.0003683013,0.001052504,0.000340374,0.0007885375,0.0003731323,0.001475355,0.001560961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006340967,"about_ca_system_score_gemma":0.0004692144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007106111,"about_ca_topic_score_gemma":0.001195003,"domain_scores_codex":[0.9998983,0.00001736343,0.000008391989,0.00001743166,0.00004209847,0.00001645942],"domain_scores_gemma":[0.999928,0.00002057164,0.00001278231,0.00000379327,0.00002171874,0.00001322613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002150208,0.0003325839,0.0001498383,0.007147886,0.0001133082,0.0006994776,0.00006132518,0.001709836,0.04614975,0.007811519,0.02678394,0.9088256],"study_design_scores_gemma":[0.0001430429,0.0005456226,0.0008569109,0.000802498,0.00008693174,0.002009582,0.0000278822,0.0006677977,0.0145484,0.002160959,0.9781086,0.00004170028],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001808429,0.992168,0.001680152,0.000328061,0.0005234975,0.0000327333,0.00003544045,0.00003397303,0.003389646],"genre_scores_gemma":[0.009160963,0.9835786,0.002089364,0.0004915039,0.0002693971,0.00004936036,0.0001134233,0.000007412154,0.004240008],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001758468,"threshold_uncertainty_score":0.005882621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1012937969475896,"score_gpt":0.4122051854939327,"score_spread":0.310911388546343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}