{"id":"W2042296446","doi":"10.1021/ja400691t","title":"Successive C–C Coupling of Dienes to Vicinally Dioxygenated Hydrocarbons: Ruthenium Catalyzed [4 + 2] Cycloaddition across the Diol, Hydroxycarbonyl, or Dione Oxidation Levels","year":2013,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Government of Canada; Welch Foundation","keywords":"Chemistry; Cycloaddition; Ruthenium; Intramolecular force; Diol; Catalysis; Tricyclohexylphosphine; Medicinal chemistry; Oxidative coupling of methane; Diene; Organic chemistry; Photochemistry; Phosphine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004202251,0.000254574,0.0005847741,0.00003834613,0.0002235969,0.00006984721,0.0009731615,0.0001059901,0.0001356769],"category_scores_gemma":[0.0007397716,0.0001370609,0.0006260648,0.001420867,0.0004443336,0.0002270039,0.000244125,0.0004556439,0.000008924065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885868,"about_ca_system_score_gemma":0.0001148666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000238516,"about_ca_topic_score_gemma":0.000004221961,"domain_scores_codex":[0.9976298,0.00003185847,0.0008853341,0.0002447907,0.0008442703,0.0003639242],"domain_scores_gemma":[0.996545,0.0005354848,0.001867978,0.0004598376,0.0004095887,0.0001821749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000816538,0.0001293138,0.0006093547,0.0000227298,0.0003829444,0.000001158829,0.001182148,0.0002724374,0.9944,0.000003585305,0.0006577461,0.002256965],"study_design_scores_gemma":[0.000672758,0.00003468638,0.001482725,0.00009410133,0.0001791643,0.00003323688,0.003746903,0.005492919,0.9877899,0.0001032935,0.0001526955,0.0002175883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964906,0.0001110476,0.000927613,0.00210282,0.00006842653,0.0001356784,0.00004042636,0.00002426455,0.00009912612],"genre_scores_gemma":[0.998629,0.00007140158,0.0003392084,0.0004990737,0.0002761713,0.00002627694,0.00001996687,0.00003139276,0.0001074689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006610034,"threshold_uncertainty_score":0.558918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147474345287939,"score_gpt":0.264604172429741,"score_spread":0.2531294289768616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}