{"id":"W2042319759","doi":"10.1016/j.febslet.2005.09.028","title":"BH3‐ligand regulates access of MCL‐1 to its E3 ligase","year":2005,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Molson Foundation; McGill University","keywords":"Ubiquitin ligase; HeLa; Chemistry; Ligand (biochemistry); Ubiquitin; Cell biology; In vitro; Histone; Proteasome; Molecular biology; Biology; Biochemistry; Receptor; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113981,0.0001288208,0.0001290314,0.00004936838,0.00004176579,0.00002725563,0.0002916499,0.00008047189,0.00004797113],"category_scores_gemma":[0.00005198082,0.0001243375,0.00007364833,0.00008838219,0.00003523693,0.000007073754,0.0001463398,0.00005643669,0.00005475303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009077523,"about_ca_system_score_gemma":0.00002103102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009324342,"about_ca_topic_score_gemma":0.00001092016,"domain_scores_codex":[0.9991918,0.00002781849,0.0001751097,0.0002607162,0.0001109376,0.0002336545],"domain_scores_gemma":[0.9994879,0.000008225286,0.00006104948,0.0002953478,0.00004385462,0.0001035946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005308321,0.00002451339,0.0003953857,0.00002281652,0.00002204782,0.00000204212,0.00007054351,0.0001634496,0.9779944,0.00003073978,0.01904869,0.00217229],"study_design_scores_gemma":[0.0002574256,0.00008330032,0.00106152,0.0000212856,0.000008089687,0.000005987155,0.000006987711,0.00001150281,0.9219404,0.000009144271,0.07644805,0.0001462632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917305,0.0003158987,0.000155044,0.006226056,0.00007996218,0.0002013187,0.00003004143,0.00001434424,0.001246867],"genre_scores_gemma":[0.9891722,0.00002624687,0.0006403967,0.009081969,0.0004673152,0.00002221575,0.00003719655,0.00001987983,0.0005326328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05739935,"threshold_uncertainty_score":0.5070335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678520812860576,"score_gpt":0.2665859801917607,"score_spread":0.2498007720631549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}