{"id":"W2042319759","doi":"10.1016/j.febslet.2005.09.028","title":"BH3‐ligand regulates access of MCL‐1 to its E3 ligase","year":2005,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Molson Foundation; McGill University","keywords":"Ubiquitin ligase; HeLa; Chemistry; Ligand (biochemistry); Ubiquitin; Cell biology; In vitro; Histone; Proteasome; Molecular biology; Biology; Biochemistry; Receptor; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258835,0.0001885504,0.0001469811,0.0001818506,0.0002495404,0.0004347952,0.000118874,0.0001744868,0.002190714],"category_scores_gemma":[0.0001899658,0.0001061399,0.0001393743,0.0001388938,0.0001654828,0.0002479891,0.0002327334,0.000248934,0.0009136743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005387273,"about_ca_system_score_gemma":0.000117082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000822752,"about_ca_topic_score_gemma":0.001130634,"domain_scores_codex":[0.9998941,0.00001639859,0.000004302071,0.00002268279,0.00002079653,0.00004177809],"domain_scores_gemma":[0.9999037,0.00001694368,0.00002220613,0.000006501654,0.00001773827,0.0000328931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000198414,0.000009869666,0.0009946843,0.00001960769,0.000002819209,0.00005702586,0.00001417063,0.0000512338,0.9966406,0.0001464591,0.00007550824,0.001789603],"study_design_scores_gemma":[0.00002203084,0.0001156752,0.02152427,0.000003919429,0.000006549651,0.0004655529,0.00006816177,0.002196848,0.9724027,0.0002391543,0.00294726,0.000007788695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948184,0.00201662,0.001756618,0.000103224,0.000009142238,0.000004200617,0.0001680236,0.00008150339,0.001042268],"genre_scores_gemma":[0.9978149,0.0002767141,0.0006698986,0.0000270991,0.000004425865,0.000003365236,0.0002280812,0.000010687,0.0009649369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190714,"threshold_uncertainty_score":0.007328629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678520812860576,"score_gpt":0.2665859801917607,"score_spread":0.2498007720631549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}