{"id":"W2042386520","doi":"10.1016/j.clinbiochem.2005.10.002","title":"Improved prediction of early-onset coronary artery disease using APOE ε4, BChE-K, PPARγ2 Pro12 and ENOS T-786C in a polygenic model","year":2005,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Health Canada; Heart and Stroke Foundation of Canada","keywords":"Coronary artery disease; Internal medicine; Enos; Allele; Age of onset; Apolipoprotein E; Medicine; Gastroenterology; Endocrinology; CAD; Cardiology; Biology; Disease; Nitric oxide; Genetics; Nitric oxide synthase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00413714,0.001944154,0.0012103,0.001056597,0.0007761998,0.001091233,0.001049115,0.001187189,0.002025945],"category_scores_gemma":[0.005130013,0.0004870832,0.001058301,0.0007030693,0.000501207,0.0005925374,0.0007186986,0.0008341793,0.0004063334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00038311,"about_ca_system_score_gemma":0.0008368806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006786884,"about_ca_topic_score_gemma":0.004402298,"domain_scores_codex":[0.9983109,0.001217393,0.00006607739,0.0002250445,0.00008591142,0.0000946829],"domain_scores_gemma":[0.9969161,0.001834058,0.0002707609,0.0003678838,0.0001970132,0.0004142751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02704363,0.002002119,0.9079232,0.00005822255,0.002269297,0.002678658,0.0003262172,0.02621202,0.01106342,0.0009780508,0.0006891461,0.01875603],"study_design_scores_gemma":[0.0009428279,0.00393822,0.6633045,0.00003016571,0.00258143,0.002004663,0.0002648572,0.3215261,0.001778612,0.002984379,0.0005442844,0.00009996808],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961256,0.00007109943,0.003245171,0.0001207885,0.00001701389,0.000009586128,0.0001102554,0.0000344188,0.0002659544],"genre_scores_gemma":[0.9984925,0.00003216072,0.001010156,0.00001408088,0.00001520262,0.00000787125,0.0001162294,0.00001030417,0.0003015605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006786884,"threshold_uncertainty_score":0.02187955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02759401162085305,"score_gpt":0.304589865745739,"score_spread":0.276995854124886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}