{"id":"W2042392223","doi":"10.1126/science.1162327","title":"Diversity and Complexity in DNA Recognition by Transcription Factors","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1037,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute","keywords":"Genome; Biology; Computational biology; DNA; DNA binding site; Transcription factor; Genetics; DNA sequencing; DNA-binding protein; Transcription (linguistics); Sequence motif; Binding site; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004888973,0.000179412,0.0005218496,0.0009242446,0.0003294971,0.001063761,0.0002747998,0.0004190333,0.0005629468],"category_scores_gemma":[0.001370433,0.0003178871,0.0002396843,0.0004563957,0.0006310209,0.0007002795,0.0004758797,0.0004773173,0.0002815768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689617,"about_ca_system_score_gemma":0.0001323321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002958795,"about_ca_topic_score_gemma":0.0006332527,"domain_scores_codex":[0.9992172,0.0001364877,0.000043191,0.0002545285,0.0002458042,0.0001027108],"domain_scores_gemma":[0.9992833,0.0003315569,0.00015049,0.00008362583,0.0000763326,0.00007473186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002466025,0.00002006627,0.02570756,0.0001127232,0.00008241942,0.0001221483,0.0002509446,0.001720767,0.9552128,0.001635932,0.00009610825,0.01479181],"study_design_scores_gemma":[0.00004607616,0.0004645448,0.6342577,0.0001120126,0.000259658,0.00494392,0.001049873,0.02848283,0.2855485,0.02888267,0.01577417,0.0001780406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930336,0.001431902,0.004177356,0.0001131279,0.000004004059,0.000003621922,0.00009743885,0.00004041577,0.001098418],"genre_scores_gemma":[0.996765,0.0006122406,0.001906025,0.00009158219,0.00001776748,0.000008802792,0.000198177,0.00001744421,0.0003828362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063761,"threshold_uncertainty_score":0.00258553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03222975422381295,"score_gpt":0.2335535896441704,"score_spread":0.2013238354203575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}