{"id":"W2042473102","doi":"10.1074/jbc.c600277200","title":"Erlotinib Effectively Inhibits JAK2V617F Activity and Polycythemia Vera Cell Growth","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; National Natural Science Foundation of China","keywords":"Polycythemia vera; Erlotinib; Myelofibrosis; Essential thrombocythemia; Cancer research; Janus kinase 2; Tyrosine kinase; Myeloproliferative Disorders; Cell culture; Tyrosine-kinase inhibitor; Bone marrow; Chemistry; Clonogenic assay; Medicine; In vitro; Pharmacology; Kinase; Internal medicine; Biology; Cancer; Biochemistry; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008805856,0.0002442123,0.0003016347,0.0001459779,0.0001036902,0.0002258972,0.0001534696,0.0002460481,0.0006452565],"category_scores_gemma":[0.0001231248,0.00006005652,0.0001779379,0.000115473,0.00008065507,0.00008835304,0.00009519734,0.0004243388,0.0002498097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746291,"about_ca_system_score_gemma":0.0001554137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005315003,"about_ca_topic_score_gemma":0.0009577487,"domain_scores_codex":[0.9999071,0.00001474964,0.000008740855,0.000008558935,0.0000306063,0.00003016261],"domain_scores_gemma":[0.9999541,0.0000111434,0.00001155561,0.000005677066,0.000006170153,0.00001131095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00105877,0.000690633,0.001161664,0.0001457589,0.00003510067,0.0006806472,0.00003141502,0.0009027172,0.956071,0.0002879168,0.002156743,0.03677772],"study_design_scores_gemma":[0.0006528383,0.00662972,0.02660406,0.00003235582,0.00009170755,0.007246589,0.0000515236,0.008258968,0.9267027,0.0001534015,0.02355175,0.00002441479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917578,0.003729345,0.0008002238,0.0002069991,0.00007827034,0.00003691001,0.000308316,0.0001101596,0.002972006],"genre_scores_gemma":[0.9963813,0.001068318,0.000344201,0.00005849133,0.00001429674,0.00002353257,0.0005241064,0.000006305104,0.001579474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006452565,"threshold_uncertainty_score":0.002158582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123644731734289,"score_gpt":0.2428870679811742,"score_spread":0.2305225948077453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}