{"id":"W2042473102","doi":"10.1074/jbc.c600277200","title":"Erlotinib Effectively Inhibits JAK2V617F Activity and Polycythemia Vera Cell Growth","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; National Natural Science Foundation of China","keywords":"Polycythemia vera; Erlotinib; Myelofibrosis; Essential thrombocythemia; Cancer research; Janus kinase 2; Tyrosine kinase; Myeloproliferative Disorders; Cell culture; Tyrosine-kinase inhibitor; Bone marrow; Chemistry; Clonogenic assay; Medicine; In vitro; Pharmacology; Kinase; Internal medicine; Biology; Cancer; Biochemistry; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810796,0.000194067,0.0004575471,0.00002460093,0.00005953691,0.00001946561,0.00005231802,0.0001962259,0.000108393],"category_scores_gemma":[0.000142545,0.0001160527,0.0001569116,0.0000789844,0.0001063392,0.00004794586,0.00003790872,0.0003614553,0.000004659607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009305807,"about_ca_system_score_gemma":0.00006073403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001500688,"about_ca_topic_score_gemma":3.974561e-7,"domain_scores_codex":[0.999087,0.00004028959,0.0002872745,0.0002026885,0.0001848678,0.0001978242],"domain_scores_gemma":[0.999087,0.0002599745,0.000258536,0.00007978761,0.000140132,0.0001746078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006450032,0.0008371155,0.1890594,0.00008838656,0.00006027546,0.0002001417,0.00001450805,5.857313e-7,0.8075251,0.0000151137,0.0006079803,0.0009463869],"study_design_scores_gemma":[0.001851323,0.0005959503,0.2852826,0.00006748846,0.00005215174,0.0004688094,0.00001001089,0.000003191477,0.7112452,0.0001432198,0.0001960049,0.00008409873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934999,0.0007221707,0.00002331825,0.0007121862,0.00003582639,0.0001251969,0.00001005783,0.00001358714,0.0048577],"genre_scores_gemma":[0.9986427,0.0002167987,0.000406702,0.0001072862,0.0004214343,0.000006626997,0.000005751717,0.000008722419,0.0001839353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09627994,"threshold_uncertainty_score":0.473249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0123644731734289,"score_gpt":0.2428870679811742,"score_spread":0.2305225948077453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}