{"id":"W2042502795","doi":"10.1021/ja047710f","title":"Hydrophobic Core Repacking in a Coiled-Coil Dimer via Phage Display:  Insights into Plasticity and Specificity at a Protein−Protein Interface","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Coiled coil; Chemistry; Pairing; Heptad repeat; Side chain; Helix (gastropod); Phage display; Dimer; Mutant; Crystallography; Hydrophobic effect; Steric effects; Biophysics; Stereochemistry; Peptide sequence; Biochemistry; Peptide; Gene; Polymer; Biology; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158541,0.0001729427,0.0001885166,0.0001125582,0.000154376,0.0002679279,0.0001453555,0.000165039,0.000478121],"category_scores_gemma":[0.0001511311,0.0001042205,0.0000980706,0.00009115828,0.0001891292,0.0001553616,0.0001785554,0.0002973996,0.0002081235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195039,"about_ca_system_score_gemma":0.00008504233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001732018,"about_ca_topic_score_gemma":0.0004089815,"domain_scores_codex":[0.9998776,0.0000379675,0.000005950165,0.00002032965,0.00003471292,0.0000234392],"domain_scores_gemma":[0.9999377,0.00001820884,0.00001181937,0.000005755197,0.000005628868,0.00002100068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000264381,0.00001230728,0.0002139315,0.000007132643,0.000001246055,0.0000326471,0.00001257911,0.0001272536,0.9989358,0.00008415258,0.00001037156,0.0005362416],"study_design_scores_gemma":[0.0000110851,0.0001512096,0.001311884,0.000002343199,0.000008280036,0.0003454595,0.00003122449,0.004199281,0.9929193,0.0000894441,0.0009261367,0.000004325656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967883,0.0001907071,0.002561836,0.00002710529,0.000002295392,0.000005777051,0.00001314408,0.00002070178,0.000390236],"genre_scores_gemma":[0.9967647,0.0001385042,0.002365252,0.00002865829,0.000002662597,0.000005020157,0.00005063767,0.000008551791,0.0006360664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000478121,"threshold_uncertainty_score":0.001599491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158962258317851,"score_gpt":0.2911764257006834,"score_spread":0.2752801998688983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}