{"id":"W2042515987","doi":"10.1074/jbc.c200408200","title":"Promoter-specific Activation and Demethylation by MBD2/Demethylase","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Demethylase; Molecular biology; Repressor; Promoter; Demethylation; Reporter gene; Chloramphenicol acetyltransferase; Transfection; DNA demethylation; Gene expression; Biology; DNA methylation; Chemistry; Gene; HEK 293 cells; CpG site; Regulation of gene expression; Epigenetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010596,0.0001271225,0.0001548019,0.0000187918,0.00005399176,0.00002610049,0.0001067121,0.0002618536,0.0001144109],"category_scores_gemma":[0.0002118675,0.000098321,0.00007653979,0.0000662426,0.00007373068,0.000007849868,0.00004107173,0.0001576724,0.00000183125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001530367,"about_ca_system_score_gemma":0.00000727628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.715491e-7,"about_ca_topic_score_gemma":4.691839e-8,"domain_scores_codex":[0.9991342,0.00005697749,0.0003461098,0.0001918699,0.0001318092,0.0001389796],"domain_scores_gemma":[0.999314,0.00003356081,0.0002961544,0.0001198607,0.0001300163,0.0001064364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003837155,0.0000772551,0.002891257,0.000009539894,0.00001962345,0.000001462997,0.00001301603,0.000005998087,0.9810041,0.000002045476,0.001023499,0.01491381],"study_design_scores_gemma":[0.0004023599,0.0003004933,0.001354764,0.00001079946,0.000006881904,0.00001598276,0.00002267279,0.00004007186,0.949155,0.0001717797,0.04839779,0.0001213933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862936,0.007700922,0.004943806,0.0002268243,0.00004483632,0.00005635722,0.000006320559,0.000004554281,0.0007227388],"genre_scores_gemma":[0.9941049,0.004076367,0.001208367,0.00004778959,0.0003361099,0.000002118385,0.00003546959,0.000008914611,0.0001799653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04737429,"threshold_uncertainty_score":0.4009414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817647173030906,"score_gpt":0.2457452968190121,"score_spread":0.217568825088703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}