{"id":"W2042515987","doi":"10.1074/jbc.c200408200","title":"Promoter-specific Activation and Demethylation by MBD2/Demethylase","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Demethylase; Molecular biology; Repressor; Promoter; Demethylation; Reporter gene; Chloramphenicol acetyltransferase; Transfection; DNA demethylation; Gene expression; Biology; DNA methylation; Chemistry; Gene; HEK 293 cells; CpG site; Regulation of gene expression; Epigenetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496692,0.0003629742,0.0004076368,0.0002156496,0.0001391314,0.0003004044,0.0002027835,0.0002446682,0.001280733],"category_scores_gemma":[0.0001774525,0.0002100056,0.0004006195,0.0002137118,0.0002461103,0.000204207,0.0003110565,0.0006576991,0.0004027057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003325615,"about_ca_system_score_gemma":0.0001791022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006425284,"about_ca_topic_score_gemma":0.0009202847,"domain_scores_codex":[0.9997492,0.00004127018,0.00002320823,0.00007410264,0.00006460876,0.00004748864],"domain_scores_gemma":[0.999878,0.00003241296,0.00002659049,0.0000253795,0.00001655476,0.00002096022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004288501,0.000006113617,0.0001011947,0.00003076755,0.00000334335,0.00001059541,0.000007296575,0.00002163498,0.9993142,0.00002841628,0.00001398456,0.0004196606],"study_design_scores_gemma":[0.000003789242,0.00003294464,0.000997132,0.000001359925,0.000003910696,0.00005116711,0.000006237944,0.0003025104,0.9973034,0.000009965335,0.001286293,0.000001275548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97713,0.005084369,0.01377994,0.0002073581,0.0000824425,0.00006391139,0.001492602,0.0001662074,0.001993146],"genre_scores_gemma":[0.9807272,0.001646195,0.00990043,0.00007891071,0.00001898952,0.00007862505,0.003049291,0.0000526351,0.004447747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280733,"threshold_uncertainty_score":0.004284441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817647173030906,"score_gpt":0.2457452968190121,"score_spread":0.217568825088703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}