{"id":"W2042540266","doi":"10.1074/jbc.m806580200","title":"Role of the C Terminus of the Photoreceptor ABCA4 Transporter in Protein Folding, Function, and Retinal Degenerative Diseases","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA4; Retinitis pigmentosa; Biology; Retinal degeneration; Endoplasmic reticulum; Mutant; Cell biology; ATP-binding cassette transporter; Biochemistry; Retinal; Phenotype; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000895787,0.00009137946,0.0001533911,0.000008198119,0.00003959419,0.000002368733,0.0001717065,0.0001072532,0.00003367593],"category_scores_gemma":[0.00009560472,0.00004506799,0.0001321775,0.00006422911,0.0002710405,0.000003128546,0.00004148024,0.0001046167,5.286413e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006887341,"about_ca_system_score_gemma":0.00008178108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002188732,"about_ca_topic_score_gemma":0.000001386812,"domain_scores_codex":[0.9993441,0.0000390597,0.0003083767,0.0001059019,0.000112616,0.00009000993],"domain_scores_gemma":[0.9995112,0.000007819589,0.0002745708,0.00009336817,0.00007687219,0.00003614678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002305847,0.00005660221,0.2576819,0.00001350283,0.00001558016,0.000001098485,0.00003034536,0.000002021766,0.7417473,0.000001781281,0.0001017607,0.0001174865],"study_design_scores_gemma":[0.0003161665,0.000118499,0.3058408,0.00003534475,0.000008956415,0.00002973362,0.00008776366,9.590584e-7,0.692876,0.0001119121,0.0005255511,0.00004823868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984642,0.001103603,0.000008623693,0.00008288831,0.00002633623,0.00008598156,0.000009203614,7.332001e-7,0.0002184807],"genre_scores_gemma":[0.9995779,0.0001281001,0.00006667338,0.00003474039,0.00005742244,0.000004307685,0.00000389588,0.000003366585,0.0001236362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04887128,"threshold_uncertainty_score":0.1837819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007290125812296223,"score_gpt":0.1951240780884113,"score_spread":0.1878339522761151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}