{"id":"W2042548343","doi":"10.1016/j.biotechadv.2009.04.004","title":"Applications of single-chain variable fragment antibodies in therapeutics and diagnostics","year":2009,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":260,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Monoclonal antibody; Computational biology; Recombinant DNA; Fragment (logic); Single-chain variable fragment; Antibody; Rab; Computer science; Biology; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000886295,0.001275253,0.001466556,0.002890617,0.0002701364,0.0009130464,0.001100744,0.001089646,0.002920684],"category_scores_gemma":[0.0008257932,0.0003758019,0.0005170484,0.002862049,0.0006568012,0.001345704,0.0006372693,0.001957202,0.002393716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007593836,"about_ca_system_score_gemma":0.0009489504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012294,"about_ca_topic_score_gemma":0.001891663,"domain_scores_codex":[0.9997461,0.0000312302,0.0000284139,0.00004353179,0.0001229291,0.00002780179],"domain_scores_gemma":[0.9995765,0.0002131303,0.00005059233,0.00001439598,0.0001110714,0.00003432389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008117074,0.00008826795,0.000135088,0.008277438,0.00006797519,0.0002331973,0.00003570969,0.0004009339,0.006752331,0.004188078,0.02047555,0.9592643],"study_design_scores_gemma":[0.00002121496,0.00007777409,0.0004276533,0.001036191,0.00008172666,0.0009501154,0.00002555864,0.000107344,0.002118932,0.001852491,0.9932833,0.00001772341],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001719338,0.9969566,0.0005774981,0.0001747713,0.0003241303,0.000007443839,0.00001582211,0.00001102789,0.001760802],"genre_scores_gemma":[0.0008476679,0.9968482,0.0006287507,0.0002050377,0.0002335173,0.000006515589,0.00003434268,0.00000208052,0.001193914],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002920684,"threshold_uncertainty_score":0.009770691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04251739407859668,"score_gpt":0.3651590525807458,"score_spread":0.3226416585021491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}