{"id":"W2042571235","doi":"10.1007/s007020170093","title":"Enantio-specific induction of apoptosis by an endogenous neurotoxin, N -methyl( R )salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N -(2-heptyl)- N -methylpropargylamine","year":2001,"lang":"en","type":"article","venue":"Journal of Neural Transmission","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institutes of Health; Parkinson Study Group","keywords":"Neurotoxin; Apoptosis; Endogeny; Dopaminergic; SH-SY5Y; Biology; Chemistry; Mitochondrion; Programmed cell death; Cell biology; Biochemistry; Molecular biology; Neuroblastoma; Cell culture; Dopamine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108583,0.0003032413,0.0002666858,0.0001945731,0.0001816911,0.0002042154,0.0002327175,0.0002747159,0.001076024],"category_scores_gemma":[0.0000924013,0.0001301258,0.0002942011,0.0001472063,0.0002123141,0.0001989933,0.0001611311,0.0004845176,0.0003106857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046624,"about_ca_system_score_gemma":0.0002404353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009134145,"about_ca_topic_score_gemma":0.001800959,"domain_scores_codex":[0.9998833,0.00001619142,0.00001343094,0.00001614935,0.00002618307,0.00004462015],"domain_scores_gemma":[0.9999067,0.00001660666,0.00002664037,0.00001981404,0.000009836568,0.00002038665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000241418,0.00003333496,0.0001399219,0.00001434994,0.000004483239,0.00009814644,0.00001441836,0.00004340925,0.9986571,0.0000875827,0.00003080285,0.0006349194],"study_design_scores_gemma":[0.0000280534,0.0003942055,0.001901296,0.000001905329,0.00001052607,0.0001676944,0.00002935393,0.0003640901,0.9965031,0.00003163026,0.000565297,0.000002824188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973424,0.0004600052,0.0006928726,0.0000672828,0.00002661369,0.00001251706,0.0002439483,0.00003626693,0.001118047],"genre_scores_gemma":[0.9970692,0.0004629449,0.0004684444,0.00002955014,0.000005960426,0.00001627863,0.0003193653,0.00001092731,0.001617467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076024,"threshold_uncertainty_score":0.003599644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0764813313041537,"score_gpt":0.3211558431540672,"score_spread":0.2446745118499135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}