{"id":"W2042598345","doi":"10.1089/jop.2011.0016","title":"Identification of Novel Competing β <sub>2</sub> AR Phospho-Extracellular Signal Regulated Kinase 1/2 Signaling Pathways in Human Trabecular Meshwork Cells","year":2011,"lang":"en","type":"article","venue":"Journal of Ocular Pharmacology and Therapeutics","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Adenylyl cyclase; Trabecular meshwork; Forskolin; MAPK/ERK pathway; Kinase; Signal transduction; Protein kinase A; Pertussis toxin; Agonist; Extracellular; Phosphorylation; Gs alpha subunit; Cell biology; Internal medicine; Endocrinology; Chemistry; Receptor; Biology; G protein; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001110392,0.0002043758,0.0005145344,0.0002587138,0.0001030371,0.00000923199,0.0001408828,0.0002121911,0.0000605987],"category_scores_gemma":[0.000007756602,0.0001798644,0.0002065716,0.0002509524,0.0002302935,0.00008748021,0.00002309191,0.0005679526,0.000001137171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003766917,"about_ca_system_score_gemma":0.00008580757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005975414,"about_ca_topic_score_gemma":9.672667e-7,"domain_scores_codex":[0.9980827,0.0001897216,0.001004118,0.0001863785,0.0002696326,0.000267437],"domain_scores_gemma":[0.9986512,0.00006837612,0.000779284,0.000112927,0.0002626228,0.0001255918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006603155,0.001156884,0.005713785,0.0001325552,0.0004728062,0.0003695046,0.0016752,0.0001008496,0.9883042,0.0002066254,0.000006381033,0.001200867],"study_design_scores_gemma":[0.004355776,0.0005927373,0.007592443,0.0001981063,0.000911925,0.0002031698,0.0006005129,0.002291299,0.9826393,0.0003413014,0.0001118501,0.0001615911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904618,0.006169443,0.002732668,0.00009324375,0.0002212944,0.0002729784,0.000003003819,0.000009839014,0.0000357497],"genre_scores_gemma":[0.9984102,0.0006812405,0.0006041002,0.0001991161,0.00006309408,0.00000245944,0.000004574344,0.00002847256,0.000006725073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007948439,"threshold_uncertainty_score":0.7334658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02871346835212353,"score_gpt":0.2721319591767005,"score_spread":0.2434184908245769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}