{"id":"W2042642856","doi":"10.1038/bjp.2008.58","title":"Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons","year":2008,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"MAPK/ERK pathway; Phosphorylation; MEK inhibitor; Epidermal growth factor; Biology; Transactivation; Proto-oncogene tyrosine-protein kinase Src; Cell biology; Chemistry; Endocrinology; Internal medicine; Molecular biology; Receptor; Biochemistry; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008236848,0.0003849866,0.0002421592,0.0001498073,0.0001310424,0.0002664741,0.0001302839,0.0002397195,0.001405564],"category_scores_gemma":[0.00008552182,0.00007940064,0.0002723924,0.00009800123,0.0001938616,0.0002674125,0.0001531449,0.0004645968,0.0003414778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003362459,"about_ca_system_score_gemma":0.0001925041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002791785,"about_ca_topic_score_gemma":0.0004984753,"domain_scores_codex":[0.9999323,0.0000108105,0.000006891258,0.00001423541,0.00001983563,0.00001596129],"domain_scores_gemma":[0.9999464,0.00001009541,0.00001585531,0.000005214922,0.00001107505,0.00001141795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003913975,0.00002408725,0.0002857592,0.0001168794,0.000004520287,0.0001968893,0.00002719549,0.00003149624,0.9963706,0.0001089519,0.00003864665,0.002403714],"study_design_scores_gemma":[0.00003857509,0.0003931347,0.01549728,0.00003099418,0.0000337124,0.0009932151,0.0001120011,0.0004704477,0.9782884,0.0001730924,0.003962328,0.000006772338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720654,0.01825119,0.005050423,0.0002467427,0.00007949973,0.0000611197,0.000481391,0.00007678611,0.003687438],"genre_scores_gemma":[0.9856896,0.007527128,0.003328983,0.0001058332,0.00003996165,0.00009926305,0.0005034534,0.00001129184,0.002694482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405564,"threshold_uncertainty_score":0.004702091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05537970336186927,"score_gpt":0.3271092413192785,"score_spread":0.2717295379574092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}