{"id":"W2042666528","doi":"10.1038/nrrheum.2014.140","title":"Pharmacogenetics: can genes determine treatment efficacy and safety in JIA?","year":2014,"lang":"en","type":"review","venue":"Nature Reviews Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"","keywords":"Medicine; Pharmacogenomics; Pharmacogenetics; Etanercept; Adverse effect; Candidate gene; Arthritis; Bioinformatics; Biomarker discovery; Personalized medicine; Gene; Pharmacology; Internal medicine; Rheumatoid arthritis; Proteomics; Genetics; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002334353,0.0007315748,0.003162142,0.001108744,0.0001962594,0.001232687,0.001181301,0.001472497,0.002631595],"category_scores_gemma":[0.004112388,0.0002891341,0.0009556081,0.001481892,0.0009623157,0.001082202,0.0006195903,0.002310983,0.0006581823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006858665,"about_ca_system_score_gemma":0.001255022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001544219,"about_ca_topic_score_gemma":0.002520646,"domain_scores_codex":[0.9993364,0.0002232352,0.000101245,0.0001094772,0.0001864499,0.00004318397],"domain_scores_gemma":[0.9977367,0.001749267,0.0002029203,0.00004636066,0.0002140809,0.00005064602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002415549,0.00007102533,0.00172957,0.008987208,0.0006726529,0.0002034886,0.00003861485,0.000336443,0.0009014521,0.005043213,0.02636418,0.9554106],"study_design_scores_gemma":[0.000341494,0.0003247026,0.01154515,0.01922567,0.002596513,0.002921483,0.0002184837,0.0005013019,0.0008820347,0.02157984,0.9397566,0.0001066888],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001592228,0.9980201,0.0001832236,0.001099486,0.0001854166,0.000002457418,0.00002813353,0.000004322745,0.0003176771],"genre_scores_gemma":[0.002153118,0.9955168,0.0003963797,0.001107953,0.0005594966,0.000007179438,0.00004796196,0.000002200751,0.0002089298],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003162142,"threshold_uncertainty_score":0.01234543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04557886032653095,"score_gpt":0.4021039592590214,"score_spread":0.3565250989324905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}