{"id":"W2042682129","doi":"10.1016/j.jcf.2014.09.012","title":"Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: New pathologic observations","year":2014,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Respiratory epithelium; Endoplasmic reticulum; Pathogenesis; Mutant; Lung; Mutation; Cell biology; Pathology; Medicine; Epithelial sodium channel; Mucus; Biology; Immunology; Epithelium; Chemistry; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000883836,0.0002024503,0.0009143745,0.000454202,0.00003226284,0.00001479277,0.0003879705,0.0001218436,0.0001661973],"category_scores_gemma":[0.004403811,0.0001525813,0.0002589595,0.0005639502,0.0001958047,0.0002174762,0.0001019421,0.000363532,0.000009847533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001193176,"about_ca_system_score_gemma":0.0003553602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051548,"about_ca_topic_score_gemma":0.00001438664,"domain_scores_codex":[0.9969745,0.0001683626,0.001389332,0.0001907064,0.0009238209,0.0003533275],"domain_scores_gemma":[0.9967173,0.001049896,0.001035589,0.0004230443,0.0005015389,0.0002726044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001076939,0.0003563302,0.01114673,0.0004674785,0.0000716963,0.00005257341,0.0004222948,0.0008381251,0.9786236,0.00009008063,0.0007856911,0.006068502],"study_design_scores_gemma":[0.007045284,0.006741261,0.1836072,0.004220394,0.000329174,0.0002423684,0.0004456074,0.00188587,0.7860785,0.005136908,0.003983058,0.0002843197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991012,0.001432151,0.006023841,0.0007019182,0.0002968147,0.0002992914,0.00005965341,0.000009389493,0.000164978],"genre_scores_gemma":[0.9082896,0.0002061262,0.0910414,0.00005718354,0.0001817951,0.000003437633,0.000005595175,0.00002330519,0.0001916022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192545,"threshold_uncertainty_score":0.6222084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775970726360588,"score_gpt":0.2802424399914054,"score_spread":0.2624827327277995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}