{"id":"W2042693531","doi":"10.1074/jbc.m706296200","title":"Diversity of Penicillin-binding Proteins","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; York University","funders":"","keywords":"Penicillin binding proteins; Peptidoglycan; Staphylococcus aureus; Microbiology; Antibiotics; Penicillin; Biochemistry; Binding site; Biology; Chemistry; Cell wall; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686943,0.0002716302,0.0002583279,0.0005819701,0.0001792023,0.000572471,0.0002079021,0.0003598539,0.001275601],"category_scores_gemma":[0.0002501813,0.00009432409,0.0001556371,0.0006118081,0.0001576099,0.00026323,0.0003384871,0.0003216625,0.0008694858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002264039,"about_ca_system_score_gemma":0.0001500964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002827845,"about_ca_topic_score_gemma":0.0002501703,"domain_scores_codex":[0.9997733,0.00003198717,0.00001572512,0.00006787188,0.00007805147,0.0000330819],"domain_scores_gemma":[0.9998722,0.00001924555,0.00002396011,0.00001207968,0.00002880334,0.00004369071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001262012,0.00003245165,0.00633991,0.0001123832,0.00003644569,0.0003878062,0.0000661741,0.0001867325,0.95514,0.001438951,0.0007421811,0.03539088],"study_design_scores_gemma":[0.00004274278,0.0006342306,0.2362158,0.0001226216,0.0001642218,0.01979927,0.0004270397,0.002838098,0.4320063,0.006229536,0.3014627,0.00005742742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9333639,0.03129142,0.01035156,0.001114567,0.00009898796,0.00003587199,0.002563749,0.0003122147,0.02086771],"genre_scores_gemma":[0.9673327,0.009334245,0.008249294,0.0004713433,0.00006998961,0.00003015396,0.005085954,0.00004662882,0.00937972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275601,"threshold_uncertainty_score":0.004267275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235001213744209,"score_gpt":0.2597099473377714,"score_spread":0.2373599352003293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}