{"id":"W2042694122","doi":"10.1128/jvi.02570-08","title":"Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF-κB, and IRF3 Pathways","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Public Health Agency; Public Health Agency of Canada","keywords":"IRF3; Biology; Protein kinase R; Interferon; Tumor necrosis factor alpha; Interferon regulatory factors; Cytokine; Vaccinia; EIF-2 kinase; Virus; Signal transduction; NF-κB; NFKB1; Virology; Cell biology; Molecular biology; Protein kinase A; Immunology; Immune system; Phosphorylation; Transcription factor; Innate immune system; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217905,0.0000924844,0.0003294311,0.00006239596,0.00005662416,0.000002996447,0.00004620217,0.0001092732,0.0001016276],"category_scores_gemma":[0.00008258566,0.00005297312,0.0001122416,0.00009076989,0.00007806349,0.0001222806,0.00003309505,0.0001628304,0.000001445993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001889262,"about_ca_system_score_gemma":0.00003418417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003123591,"about_ca_topic_score_gemma":0.000007514312,"domain_scores_codex":[0.9991999,0.00008561496,0.000384735,0.00008091814,0.0001465008,0.0001023439],"domain_scores_gemma":[0.999193,0.00006876345,0.0004242168,0.0001438942,0.0001266554,0.00004347481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006700014,0.0006642514,0.01273587,0.00002820821,0.00006953776,0.00006539602,0.0004716163,0.00001705163,0.9779418,0.0001086119,0.0004918672,0.006735829],"study_design_scores_gemma":[0.002703847,0.00204,0.1500957,0.0001634832,0.0002111341,0.0004402305,0.00008936899,0.000005981573,0.8403264,0.001511618,0.002367851,0.0000443777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981914,0.0004675983,0.00006182359,0.0005238782,0.0001407604,0.00009738569,0.00001495488,0.000004109065,0.000498051],"genre_scores_gemma":[0.9987069,0.0006662303,0.000292233,0.000217326,0.00009621842,8.306928e-7,0.000001212427,0.000005387401,0.00001359816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1376153,"threshold_uncertainty_score":0.2160181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02195718248356411,"score_gpt":0.2812367550735617,"score_spread":0.2592795725899976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}