{"id":"W2042694122","doi":"10.1128/jvi.02570-08","title":"Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF-κB, and IRF3 Pathways","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Public Health Agency; Public Health Agency of Canada","keywords":"IRF3; Biology; Protein kinase R; Interferon; Tumor necrosis factor alpha; Interferon regulatory factors; Cytokine; Vaccinia; EIF-2 kinase; Virus; Signal transduction; NF-κB; NFKB1; Virology; Cell biology; Molecular biology; Protein kinase A; Immunology; Immune system; Phosphorylation; Transcription factor; Innate immune system; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002066005,0.000387419,0.0002829741,0.0002080802,0.0001154119,0.0003188158,0.0001415772,0.0002300641,0.0006912542],"category_scores_gemma":[0.0001604584,0.0001319081,0.0003584031,0.0001216568,0.0002628534,0.0001814131,0.0001836647,0.0005549251,0.0002245499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900321,"about_ca_system_score_gemma":0.0002399821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003015067,"about_ca_topic_score_gemma":0.0003537803,"domain_scores_codex":[0.9998044,0.00003466611,0.00002547375,0.00002595991,0.00004006835,0.00006939047],"domain_scores_gemma":[0.999877,0.00002866269,0.00003895067,0.0000161194,0.00001293534,0.00002620602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704723,0.00004032918,0.0001422814,0.00002180608,0.000004231505,0.00002115793,0.000008484526,0.00002627621,0.9986626,0.00004250561,0.00001763329,0.0008421165],"study_design_scores_gemma":[0.00004284257,0.0005540916,0.003489418,0.000005093737,0.0000160621,0.0002224129,0.00002079158,0.0005688488,0.9932095,0.0000545458,0.001812053,0.000004173046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949542,0.001616061,0.00179898,0.00007934855,0.00003756025,0.00002770547,0.0002160477,0.00009370343,0.001176346],"genre_scores_gemma":[0.9953828,0.0008104835,0.001772125,0.00006683881,0.00001662636,0.00003313649,0.0004074118,0.00002429889,0.001486202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006912542,"threshold_uncertainty_score":0.002312541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02195718248356411,"score_gpt":0.2812367550735617,"score_spread":0.2592795725899976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}