{"id":"W2042711924","doi":"10.1038/nature03871","title":"Exotoxin A–eEF2 complex structure indicates ADP ribosylation by ribosome mimicry","year":2005,"lang":"en","type":"article","venue":"Nature","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Elongation factor; Diphtheria toxin; ADP-ribosylation; Ribosome; Pseudomonas exotoxin; Cholera toxin; Cleavage (geology); NAD+ kinase; Conformational change; Biology; Stereochemistry; Chemistry; Biochemistry; RNA; Toxin; Microbiology; Genetics; Pseudomonas aeruginosa; Enzyme; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.000124158,0.0003108772,0.0003209067,0.0001380649,0.0002991974,0.00003663917,0.0004399903,0.003001513,0.005470735],"category_scores_gemma":[0.00005526148,0.0002691974,0.0001149767,0.000205294,0.0001255223,0.0002182551,0.00009904183,0.003000568,0.0007158585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008216124,"about_ca_system_score_gemma":0.00003844075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001529739,"about_ca_topic_score_gemma":0.00002813685,"domain_scores_codex":[0.998549,0.0001224541,0.0003172764,0.0004370267,0.0000809378,0.0004932635],"domain_scores_gemma":[0.9992847,0.00006081555,0.0001800129,0.000370613,0.00006658278,0.00003725454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005470187,0.00007921785,0.0002138833,0.000008325372,0.00008577146,0.00000121332,0.000169357,0.000004722803,0.8931653,0.001796216,0.09709339,0.007327933],"study_design_scores_gemma":[0.000952987,0.00007196173,0.004927597,0.00001369094,0.00002487053,0.00003914445,0.00005518377,0.0000105847,0.5028684,0.0006319215,0.4901451,0.0002586246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706814,0.01998315,0.0002062323,0.00390144,0.001418917,0.0005735257,0.001257636,0.0003153382,0.001662324],"genre_scores_gemma":[0.9906504,0.00009952675,0.001070458,0.002901685,0.0001650531,0.00001251103,0.002131732,0.00003851509,0.00293016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3930517,"threshold_uncertainty_score":0.999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006806872848765464,"score_gpt":0.2338388567880528,"score_spread":0.2270319839392873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}