{"id":"W2042711924","doi":"10.1038/nature03871","title":"Exotoxin A–eEF2 complex structure indicates ADP ribosylation by ribosome mimicry","year":2005,"lang":"en","type":"article","venue":"Nature","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Elongation factor; Diphtheria toxin; ADP-ribosylation; Ribosome; Pseudomonas exotoxin; Cholera toxin; Cleavage (geology); NAD+ kinase; Conformational change; Biology; Stereochemistry; Chemistry; Biochemistry; RNA; Toxin; Microbiology; Genetics; Pseudomonas aeruginosa; Enzyme; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001564896,0.0002494315,0.0001796576,0.000160313,0.000310833,0.0004634552,0.0002516933,0.000511973,0.002315108],"category_scores_gemma":[0.0002721715,0.0001756554,0.0002087614,0.0001573822,0.0002760484,0.0003531888,0.0002439319,0.0006806014,0.0003659075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004686241,"about_ca_system_score_gemma":0.0001247342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005073465,"about_ca_topic_score_gemma":0.0005001575,"domain_scores_codex":[0.9998838,0.00002499299,0.000006026062,0.00002918977,0.00001888271,0.00003717249],"domain_scores_gemma":[0.9998028,0.00004706699,0.00005310712,0.0000401504,0.00001431326,0.00004260413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004779475,0.00002979885,0.0007468329,0.00001842385,0.00001506421,0.0002692727,0.00002328245,0.0002411338,0.9964176,0.0007678855,0.0001673929,0.0008252492],"study_design_scores_gemma":[0.00002654779,0.0001818054,0.008084015,0.000003806392,0.000012454,0.0005794485,0.00003759577,0.00365569,0.9853548,0.0002743928,0.001781783,0.000007768804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995225,0.0003764409,0.002379279,0.0001488511,0.00003426349,0.000005403628,0.00007877359,0.00005158335,0.001700316],"genre_scores_gemma":[0.9978648,0.00008608351,0.0006093661,0.00004504742,0.000008399365,0.000004107555,0.0001732905,0.00001351362,0.001195492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315108,"threshold_uncertainty_score":0.007744789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006806872848765464,"score_gpt":0.2338388567880528,"score_spread":0.2270319839392873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}