{"id":"W2042715571","doi":"10.1016/j.bmc.2011.11.009","title":"Discovery of inhibitors and substrates of brassinin hydrolase: Probing selectivity with dithiocarbamate bioisosteres","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Chemistry; Carbamate; Thiocarbamate; Dithiocarbamate; Hydrolase; Cartap; Myrosinase; Stereochemistry; Alternaria brassicicola; Enzyme; Biochemistry; Organic chemistry; Glucosinolate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005252353,0.0006057338,0.000435201,0.0003997882,0.0002087543,0.0004803002,0.0005927772,0.0005155811,0.001460074],"category_scores_gemma":[0.000457395,0.0003785139,0.0002450683,0.0002849298,0.0002757296,0.0004177229,0.0002328868,0.001003422,0.0005125625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006571628,"about_ca_system_score_gemma":0.0003191875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009112404,"about_ca_topic_score_gemma":0.002456719,"domain_scores_codex":[0.9998178,0.00004418001,0.00001303504,0.0000312097,0.00004745405,0.00004646853],"domain_scores_gemma":[0.9998279,0.00006317794,0.00002969158,0.00002066956,0.00002885747,0.00002978441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004428262,0.0001540169,0.0003501006,0.0001530169,0.0000280099,0.0001677689,0.00006189682,0.001175968,0.9844794,0.0008654895,0.0003336928,0.01178781],"study_design_scores_gemma":[0.00005765201,0.0004696075,0.0003151957,0.000007767116,0.00002823932,0.0001734571,0.00001571107,0.001270422,0.9940498,0.00006936217,0.003533378,0.000009392727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9366256,0.0190521,0.02946568,0.0007675162,0.0001000145,0.0004934735,0.0009548669,0.0006039176,0.01193678],"genre_scores_gemma":[0.97679,0.008964297,0.008650657,0.0001739918,0.00003010652,0.0001136084,0.0008399073,0.00005761219,0.004379842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460074,"threshold_uncertainty_score":0.004884422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289564940005073,"score_gpt":0.1700012420106143,"score_spread":0.1571055926105636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}