{"id":"W2042717395","doi":"10.1016/s0378-4347(00)00457-6","title":"High-performance liquid chromatographic assays for a second-generation novel oral iron chelator (APCP363) and their application to pharmacokinetic studies in rats","year":2001,"lang":"en","type":"article","venue":"Journal of Chromatography B Biomedical Sciences and Applications","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Apotex (Canada)","funders":"","keywords":"Urine; Feces; Pharmacokinetics; Chromatography; High-performance liquid chromatography; Chemistry; Pharmacology; Biology; Microbiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000958389,0.0009089325,0.0007207484,0.0006919183,0.0006757514,0.0004507799,0.0004636783,0.001055172,0.001109554],"category_scores_gemma":[0.001495287,0.0005617397,0.0004838257,0.0004732056,0.0005422733,0.0004289005,0.0002403496,0.00148274,0.000778268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00059004,"about_ca_system_score_gemma":0.001404397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003951233,"about_ca_topic_score_gemma":0.005661468,"domain_scores_codex":[0.9995915,0.0001258702,0.00002240614,0.00007756132,0.0001180483,0.00006451477],"domain_scores_gemma":[0.9993834,0.0001905492,0.0001114688,0.00007271756,0.0001329716,0.0001088466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002150274,0.0003211361,0.0006765374,0.0001344483,0.00005862955,0.0001035486,0.00008186415,0.0003733567,0.9752979,0.000318597,0.0005261605,0.01995754],"study_design_scores_gemma":[0.0001796019,0.001502817,0.002613998,0.00001148092,0.00009989415,0.0004809038,0.00002092462,0.003211403,0.9888114,0.000149231,0.002883361,0.00003498965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7598637,0.01202344,0.2153007,0.001262052,0.0005607442,0.001267525,0.001465589,0.003567898,0.004688264],"genre_scores_gemma":[0.8248798,0.005978954,0.15185,0.0008590698,0.0002239095,0.001155556,0.001471665,0.0003153988,0.01326564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003951233,"threshold_uncertainty_score":0.007856429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02677559450203767,"score_gpt":0.3128299971224658,"score_spread":0.2860544026204281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}