{"id":"W2042728718","doi":"10.1038/nm.2306","title":"Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity","year":2011,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":405,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Alum; Cell biology; Inflammasome; Chemistry; Immune system; Dendritic cell; Adjuvant; Cell adhesion molecule; Receptor; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002396925,0.0001606781,0.0002673371,0.0001411893,0.0001180632,0.000003672686,0.0001338329,0.0004318779,0.001870284],"category_scores_gemma":[0.0001392443,0.0001102087,0.00005238116,0.0001148051,0.0001170179,0.0001453381,0.00001941371,0.0005503313,0.000160095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002300456,"about_ca_system_score_gemma":0.0000392488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003327026,"about_ca_topic_score_gemma":0.00001549426,"domain_scores_codex":[0.9991485,0.0000867339,0.0002414741,0.0002228951,0.00005291574,0.0002474232],"domain_scores_gemma":[0.9993294,0.0001301115,0.0001242334,0.0001924309,0.0002043285,0.00001953101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002253354,0.00009023345,0.00007264361,0.000117593,0.0001152186,0.000005574294,0.001948774,2.299467e-7,0.9842299,0.000476195,0.009249419,0.001440814],"study_design_scores_gemma":[0.002900261,0.000749586,0.00075797,0.0001427084,0.0001704392,0.00008485176,0.0003616012,0.00001784932,0.9411453,0.00003139061,0.05350999,0.0001280468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779622,0.005924339,0.001780233,0.001750148,0.003881894,0.0006499145,0.0000110249,0.00009708229,0.00794315],"genre_scores_gemma":[0.9938782,0.0001090408,0.0001256223,0.0007169877,0.0002478434,0.00002587883,0.0001375264,0.00001759707,0.004741277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04426057,"threshold_uncertainty_score":0.9990422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259085845758443,"score_gpt":0.2560159275896542,"score_spread":0.2434250691320698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}