{"id":"W2042728718","doi":"10.1038/nm.2306","title":"Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity","year":2011,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":405,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Alum; Cell biology; Inflammasome; Chemistry; Immune system; Dendritic cell; Adjuvant; Cell adhesion molecule; Receptor; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002860054,0.0005325556,0.0002676841,0.0001965907,0.000322411,0.0006811536,0.000208055,0.0005086358,0.002697132],"category_scores_gemma":[0.0005308459,0.0002126711,0.0003018061,0.0001160049,0.0002839156,0.0004128906,0.0006168319,0.000822919,0.001728145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343376,"about_ca_system_score_gemma":0.0005015301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003163449,"about_ca_topic_score_gemma":0.0003396722,"domain_scores_codex":[0.9997296,0.00006211162,0.00001973516,0.00003341477,0.00007393861,0.00008118617],"domain_scores_gemma":[0.9996917,0.00006938741,0.00007206375,0.00004231991,0.00006031956,0.00006419012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003318,0.00002539286,0.0002839958,0.00004048092,0.000004297022,0.0000648067,0.000009098011,0.00004216674,0.9972796,0.0002542095,0.00006506277,0.001599037],"study_design_scores_gemma":[0.00002673861,0.0001665642,0.001841491,0.000009309719,0.00001036356,0.000171383,0.00002717015,0.0003057132,0.9949489,0.000199859,0.00228804,0.00000459278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793053,0.005011439,0.008486414,0.0007150037,0.0002353101,0.00009031854,0.0004115749,0.0001739618,0.005570555],"genre_scores_gemma":[0.9923661,0.001246594,0.002559621,0.0001193562,0.00003977283,0.000031648,0.0003792239,0.00004076688,0.003216945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002697132,"threshold_uncertainty_score":0.009022832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259085845758443,"score_gpt":0.2560159275896542,"score_spread":0.2434250691320698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}