{"id":"W2042737626","doi":"10.1016/j.msard.2013.10.006","title":"Impact of prior treatment status and reasons for discontinuation on the efficacy and safety of fingolimod: Subgroup analyses of the Fingolimod Research Evaluating Effects of Daily Oral Therapy in Multiple Sclerosis (FREEDOMS) study","year":2013,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; London Health Sciences Centre; Western University","funders":"Novartis Pharma; EMD Serono; Genentech; Daiichi Sankyo Europe; Sanofi; European Commission; Glenmark Pharmaceuticals; Eli Lilly and Company; CSL Behring; Novartis Pharmaceuticals Corporation; Biogen; Novo Nordisk; Teva Pharmaceutical Industries; National Research Foundation; Universitätsspital Basel","keywords":"Fingolimod; Medicine; Glatiramer acetate; Discontinuation; Placebo; Adverse effect; Multiple sclerosis; Internal medicine; Disease; Immunology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008187333,0.000190425,0.0004018341,0.0001168465,0.0001657946,0.00001902555,0.0001246611,0.0001177322,0.000002833474],"category_scores_gemma":[0.001211787,0.0001044558,0.0001471872,0.0002818857,0.0003484779,0.00001468019,0.00009088276,0.0001038308,3.955599e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001592013,"about_ca_system_score_gemma":0.0000536265,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007059963,"about_ca_topic_score_gemma":0.000491221,"domain_scores_codex":[0.998239,0.0004828165,0.0004734394,0.0003231259,0.0002224237,0.0002591827],"domain_scores_gemma":[0.9982378,0.0009157163,0.0003047035,0.0003305975,0.000160625,0.00005056426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007441539,0.0007706487,0.2933739,0.00003146791,0.0002571605,1.166067e-8,0.002807174,0.001060326,0.6735262,0.000007527397,0.000003792817,0.02741757],"study_design_scores_gemma":[0.01082459,0.002894532,0.908747,0.0002112896,0.00008688853,8.367264e-8,0.001308268,0.003842145,0.07196199,0.00002334888,0.000001328767,0.00009853895],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946352,0.002800857,0.00001693925,0.00004221868,0.00002981571,0.002425596,0.00004089234,0.000002612435,0.000005850099],"genre_scores_gemma":[0.9959103,0.003799195,0.0001089806,0.000003440635,0.000009484745,0.0001261492,0.00001671843,0.00001987305,0.000005789308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6153731,"threshold_uncertainty_score":0.9995521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0934681497190447,"score_gpt":0.349094815101173,"score_spread":0.2556266653821283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}