{"id":"W2042745266","doi":"10.1038/nature13999","title":"Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":570,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Intrinsically disordered proteins; Biophysics; Chemistry; Cell biology; Protein folding; Folding (DSP implementation); EIF4E; Translation (biology); Biology; Biochemistry; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123008,0.0001080693,0.0001108933,0.00002041518,0.00003892639,0.00001019492,0.0001538299,0.0009204524,0.000007373106],"category_scores_gemma":[0.0001427747,0.00009784697,0.00004701255,0.00006690529,0.00003556659,0.000005002632,0.00004851179,0.0003704306,0.000001101724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007481678,"about_ca_system_score_gemma":0.0000351479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001135902,"about_ca_topic_score_gemma":0.00001848254,"domain_scores_codex":[0.9993258,0.00003879795,0.0001293388,0.0002399672,0.0001411841,0.0001249718],"domain_scores_gemma":[0.9994588,0.000004093945,0.00008852904,0.0003174502,0.00007941582,0.00005172717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105551,0.00002740025,0.0002039174,0.00001736691,0.00001519059,2.694221e-7,0.00001666562,0.00001051778,0.9697153,0.002554703,0.0004107102,0.02692238],"study_design_scores_gemma":[0.000543695,0.0003921645,0.001590748,0.00001705745,0.00001037775,0.000004333719,0.00001288819,0.0003746331,0.9578445,0.005564981,0.03346251,0.0001820908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995294,0.0009868941,0.002548575,0.0001145403,0.00006045148,0.0002194467,0.0000106444,0.00001364326,0.0007517427],"genre_scores_gemma":[0.9970924,0.00001092003,0.002059163,0.0002610689,0.0001192762,0.0000117459,0.0001856793,0.00001685811,0.0002429016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0330518,"threshold_uncertainty_score":0.7099372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001545065392014543,"score_gpt":0.2157731459082559,"score_spread":0.2142280805162414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}