{"id":"W2042745266","doi":"10.1038/nature13999","title":"Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":570,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Intrinsically disordered proteins; Biophysics; Chemistry; Cell biology; Protein folding; Folding (DSP implementation); EIF4E; Translation (biology); Biology; Biochemistry; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233529,0.0001977393,0.0002101045,0.0001075963,0.0003384563,0.000491968,0.0003177665,0.0002741518,0.0006394257],"category_scores_gemma":[0.0002497237,0.0001817505,0.0002146316,0.00009461695,0.000411203,0.0003848583,0.0002611159,0.0004483927,0.0002039716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003523355,"about_ca_system_score_gemma":0.000181366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002776199,"about_ca_topic_score_gemma":0.0003230232,"domain_scores_codex":[0.9999298,0.00001260983,0.000006496246,0.00002040832,0.00001369802,0.00001707314],"domain_scores_gemma":[0.9998856,0.00003123331,0.00001968855,0.00001785839,0.000008297958,0.00003737018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004163341,0.00006958205,0.001047936,0.00004026044,0.00001285169,0.0004265355,0.00006764956,0.003606088,0.9859687,0.004176606,0.0002320557,0.003935437],"study_design_scores_gemma":[0.00008646463,0.0003708031,0.004425752,0.000011371,0.00003244982,0.00064119,0.0000897701,0.07382137,0.9126374,0.005353725,0.002480383,0.00004933192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945168,0.0001745151,0.003797943,0.0002135229,0.00005429778,0.000008770776,0.00002281221,0.00007884693,0.001132392],"genre_scores_gemma":[0.9983614,0.00008915382,0.001122421,0.00004193546,0.000008201278,0.000003272866,0.00001993244,0.00001097794,0.0003427857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006394257,"threshold_uncertainty_score":0.002556384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001545065392014543,"score_gpt":0.2157731459082559,"score_spread":0.2142280805162414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}