{"id":"W2042765773","doi":"10.1128/jvi.03406-13","title":"Histone Deacetylase Inhibitors Potentiate Vesicular Stomatitis Virus Oncolysis in Prostate Cancer Cells by Modulating NF-κB-Dependent Autophagy","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Prostate Cancer Canada; U.S. Department of Defense","keywords":"Vorinostat; Oncolytic virus; Vesicular stomatitis virus; Biology; Autophagy; Histone deacetylase; Histone deacetylase inhibitor; Cancer research; Interferon; Programmed cell death; Cell biology; Cancer cell; Histone; Apoptosis; Virology; Cancer; Virus; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055798,0.0003340002,0.000344361,0.00024276,0.000128925,0.0002270568,0.0001637188,0.0001482389,0.001210191],"category_scores_gemma":[0.00007153046,0.0001286814,0.0004330749,0.0001980308,0.0001539107,0.0001347836,0.0001335719,0.0006913856,0.000230432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344593,"about_ca_system_score_gemma":0.000311499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304117,"about_ca_topic_score_gemma":0.003597263,"domain_scores_codex":[0.9999163,0.00001086295,0.000008333043,0.00001384642,0.00002134433,0.00002924617],"domain_scores_gemma":[0.9999534,0.000007968396,0.00001093691,0.000005863732,0.000006862547,0.00001489507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004520629,0.0002232202,0.0001828741,0.0001052564,0.00002369693,0.00003004571,0.00002342438,0.0002476564,0.9939935,0.00009055142,0.0001944966,0.004433266],"study_design_scores_gemma":[0.0001067816,0.002757128,0.005625826,0.000009636266,0.00006203302,0.00009334479,0.00003400539,0.001243273,0.9864114,0.00007172168,0.003574593,0.00001021333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912035,0.00359882,0.001166711,0.0001572842,0.0001076282,0.00006547919,0.0006081045,0.000248578,0.0028439],"genre_scores_gemma":[0.9949189,0.001790749,0.0007622558,0.00008807205,0.00001818893,0.00004029615,0.0006050446,0.00001822077,0.001758262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304117,"threshold_uncertainty_score":0.004048467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005824669598903928,"score_gpt":0.2766194529834022,"score_spread":0.2707947833844983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}