{"id":"W2042795748","doi":"10.1080/1475636021000002067","title":"Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Medical Research Council Canada; Shionogi","keywords":"Chemistry; Androgen receptor; Aminoglutethimide; Androgen; Androsterone; Pregnenolone; Dehydrogenase; Steroid; Hydroxysteroid dehydrogenase; Internal medicine; Enzyme; Endocrinology; Stereochemistry; Biochemistry; Aromatase; Biology; Hormone; Prostate cancer; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001069084,0.0004322498,0.0002852309,0.0001754081,0.0000936385,0.0001513334,0.0001591647,0.0001583424,0.001482724],"category_scores_gemma":[0.00009502438,0.0001152288,0.000198866,0.0003344679,0.0001221698,0.0001576191,0.000115479,0.0002912637,0.0006183712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193809,"about_ca_system_score_gemma":0.0002905573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005824841,"about_ca_topic_score_gemma":0.001365137,"domain_scores_codex":[0.9999174,0.00001474389,0.00001067307,0.00001127096,0.00002059753,0.00002523865],"domain_scores_gemma":[0.999927,0.00001072077,0.00002037552,0.000009029981,0.00001485439,0.0000179707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002097516,0.00004045654,0.0001781222,0.00009865865,0.00001164707,0.0001073608,0.00002258467,0.0001768443,0.9944394,0.0001058476,0.00004050028,0.004568885],"study_design_scores_gemma":[0.0000283502,0.0009291863,0.001229028,0.00000544758,0.00003164836,0.0002543021,0.0000163045,0.00008942017,0.9915307,0.00002157245,0.005856922,0.000007091526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760321,0.01176842,0.004340727,0.00007707666,0.0000672329,0.0001242026,0.001082726,0.00008209119,0.006425521],"genre_scores_gemma":[0.977805,0.009907113,0.005535404,0.00004577847,0.000030983,0.00007623312,0.001083303,0.00004006119,0.005476014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482724,"threshold_uncertainty_score":0.004960239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405449095931721,"score_gpt":0.2369394863192172,"score_spread":0.2228849953599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}