{"id":"W2042795748","doi":"10.1080/1475636021000002067","title":"Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Medical Research Council Canada; Shionogi","keywords":"Chemistry; Androgen receptor; Aminoglutethimide; Androgen; Androsterone; Pregnenolone; Dehydrogenase; Steroid; Hydroxysteroid dehydrogenase; Internal medicine; Enzyme; Endocrinology; Stereochemistry; Biochemistry; Aromatase; Biology; Hormone; Prostate cancer; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002619903,0.0002345565,0.0003519196,0.00005878198,0.0001247765,0.00001942237,0.00004294508,0.0002944734,0.00002650112],"category_scores_gemma":[0.0001613737,0.0001828633,0.00008860347,0.00008832269,0.0002257658,0.00003487589,0.00003721749,0.0002445842,8.297886e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007601304,"about_ca_system_score_gemma":0.00003233155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.876122e-7,"about_ca_topic_score_gemma":4.533446e-7,"domain_scores_codex":[0.9988319,0.00008868208,0.0003985703,0.0002702324,0.0002175835,0.0001930316],"domain_scores_gemma":[0.9989715,0.00009533444,0.0004624949,0.00009624552,0.0001865977,0.0001878227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001483129,0.0002445566,0.0001088508,0.0001934457,0.00009808203,0.000008987869,0.0001342906,0.00000457703,0.9956752,0.000002305003,0.001768571,0.0002780248],"study_design_scores_gemma":[0.001932298,0.001098704,0.00002239785,0.000490975,0.00008782841,0.0003008226,0.0001381466,0.00005665201,0.9955258,0.000007825816,0.0001562709,0.0001822719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979168,0.001140054,0.0002245825,0.000233171,0.00008158463,0.0002422142,0.00006559103,0.000006365534,0.00008967906],"genre_scores_gemma":[0.9985784,0.0008138838,0.0001230262,0.00006958092,0.0001985917,0.00001275241,0.0001015679,0.00001901372,0.00008317354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016123,"threshold_uncertainty_score":0.7456951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405449095931721,"score_gpt":0.2369394863192172,"score_spread":0.2228849953599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}