{"id":"W2042805913","doi":"10.1136/bmj.39136.682083.ae","title":"Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials","year":2007,"lang":"en","type":"review","venue":"BMJ","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":456,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Canadian College of Naturopathic Medicine; Western University; McMaster University","funders":"Canadian Institutes of Health Research; Mayo Foundation for Medical Education and Research","keywords":"Medicine; End point; Randomized controlled trial; Relative risk; Clinical trial; Clinical endpoint; Internal medicine; Confidence interval; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.480403,0.004381018,0.02494362,0.01516892,0.001683248,0.00961583,0.006282592,0.006520772,0.003664259],"category_scores_gemma":[0.7576292,0.004671832,0.01965874,0.01811416,0.007935403,0.008836227,0.005397246,0.006415683,0.0007527891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01002706,"about_ca_system_score_gemma":0.01506442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004482682,"about_ca_topic_score_gemma":0.008791329,"domain_scores_codex":[0.204297,0.5598769,0.1753732,0.01515121,0.04415899,0.001142668],"domain_scores_gemma":[0.1320706,0.7457887,0.08646621,0.01638873,0.01817014,0.001115578],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001943394,0.00003279708,0.002629588,0.8354002,0.089085,0.0001358074,0.0008476252,0.0009420892,0.0001698398,0.003497088,0.006915757,0.05840074],"study_design_scores_gemma":[0.0106899,0.001206759,0.01095511,0.7344447,0.1628545,0.0009459571,0.001030225,0.003685386,0.001006654,0.03206896,0.04049615,0.0006157964],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002418753,0.9640229,0.01577992,0.006201118,0.002567609,0.006073469,0.001600998,0.0002401184,0.001095086],"genre_scores_gemma":[0.2202178,0.5811712,0.104738,0.01744847,0.004473244,0.06753008,0.002858517,0.000563138,0.0009996259],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.519597,"threshold_uncertainty_score":0.6407557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7630812926026873,"score_gpt":0.6042377862803687,"score_spread":0.1588435063223186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}