{"id":"W2042828682","doi":"10.1021/jm701079h","title":"Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"Pfizer","keywords":"Pharmacophore; Chemistry; Benzamide; Histone deacetylase; Enzyme; Potency; Selectivity; Structure–activity relationship; Hydroxamic acid; Biochemistry; Aryl; Combinatorial chemistry; Enzyme inhibitor; Stereochemistry; Pharmacology; In vitro; Histone; Catalysis; Alkyl; DNA; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728395,0.0004603333,0.0005085311,0.0002330965,0.0001144345,0.0002727523,0.0004886488,0.0002217003,0.002185367],"category_scores_gemma":[0.0001250171,0.000173521,0.0001918624,0.0002206076,0.0001668666,0.0002371957,0.0002007825,0.0006150877,0.0008081309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369895,"about_ca_system_score_gemma":0.0002546167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007120299,"about_ca_topic_score_gemma":0.003125807,"domain_scores_codex":[0.9998823,0.00001927392,0.000008594187,0.00001892682,0.00002780502,0.00004307483],"domain_scores_gemma":[0.9999517,0.000006962725,0.00001076336,0.000004124153,0.000009680291,0.00001682191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006587885,0.0002482301,0.0002783616,0.0002080851,0.0000261014,0.0002523884,0.00004883234,0.001013291,0.9544312,0.001865255,0.001037711,0.03993181],"study_design_scores_gemma":[0.001260419,0.00535241,0.004218025,0.00003152095,0.0001162636,0.001601333,0.00002856382,0.005345325,0.9399379,0.0004264852,0.04162871,0.00005282417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9113766,0.01895235,0.03294055,0.0007204368,0.0003918561,0.0004144904,0.00117438,0.0009050627,0.03312427],"genre_scores_gemma":[0.9541788,0.009912761,0.01965175,0.0004574046,0.0001720883,0.0001351717,0.001099567,0.00007050367,0.01432195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002185367,"threshold_uncertainty_score":0.007310808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007248053431698478,"score_gpt":0.2800483031724263,"score_spread":0.2728002497407278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}