{"id":"W2042828682","doi":"10.1021/jm701079h","title":"Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"Pfizer","keywords":"Pharmacophore; Chemistry; Benzamide; Histone deacetylase; Enzyme; Potency; Selectivity; Structure–activity relationship; Hydroxamic acid; Biochemistry; Aryl; Combinatorial chemistry; Enzyme inhibitor; Stereochemistry; Pharmacology; In vitro; Histone; Catalysis; Alkyl; DNA; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001123658,0.0002475267,0.0003427802,0.00008486596,0.0001079001,0.00001561466,0.0002162203,0.000248422,0.00002693989],"category_scores_gemma":[0.0006067864,0.000202181,0.00008454046,0.0002465216,0.0003568183,0.00001441831,0.00007470465,0.00062347,0.000001492305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502423,"about_ca_system_score_gemma":0.0004724369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002901908,"about_ca_topic_score_gemma":0.00002894478,"domain_scores_codex":[0.9979989,0.00002807742,0.0005269038,0.0003210442,0.000704752,0.0004203413],"domain_scores_gemma":[0.9982311,0.00005893863,0.0003954475,0.0002544707,0.0006236745,0.0004363656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001269023,0.0001811877,0.0002996884,0.00009745474,0.00007858224,0.0001371564,0.0001074287,0.00001093951,0.992892,0.000001005428,0.001340064,0.003585503],"study_design_scores_gemma":[0.001902763,0.001081673,0.0009658166,0.0001479161,0.00005176867,0.002346693,0.0002699631,0.000005150047,0.9897579,0.000005256192,0.003241651,0.0002234362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910441,0.002082912,0.004873507,0.0001759031,0.0001619932,0.00009002134,0.000003499766,0.00000742701,0.001560642],"genre_scores_gemma":[0.9957869,0.0001474098,0.001661306,0.0000868635,0.001234966,0.000001444213,0.00001069466,0.00003446336,0.001035923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004742836,"threshold_uncertainty_score":0.8244703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007248053431698478,"score_gpt":0.2800483031724263,"score_spread":0.2728002497407278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}