{"id":"W2042912904","doi":"10.1038/jid.2008.207","title":"Arsenite Suppresses Notch1 Signaling in Human Keratinocytes","year":2008,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; U.S. Public Health Service; McGill University","keywords":"Arsenite; Cell biology; Keratinocyte; Carcinogenesis; Intracellular; Biology; Signal transduction; Mechanism of action; Cellular differentiation; Downregulation and upregulation; Receptor; Cancer research; Chemistry; Cell culture; Biochemistry; Arsenic; Gene; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836131,0.0002773268,0.0003005567,0.0003831181,0.0003400362,0.0005853017,0.0002423426,0.0003442148,0.002293147],"category_scores_gemma":[0.0002088544,0.0002635583,0.0003664498,0.0002448843,0.0002478352,0.0002148793,0.000236082,0.0005071982,0.000537079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003132955,"about_ca_system_score_gemma":0.0003360972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002564759,"about_ca_topic_score_gemma":0.002840373,"domain_scores_codex":[0.9997135,0.00009620733,0.00002964872,0.00003338359,0.0000549406,0.00007225442],"domain_scores_gemma":[0.999843,0.00005861259,0.0000186145,0.00003574766,0.00002081008,0.00002318937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000590654,0.0001026868,0.0003171593,0.00002626389,0.00001207493,0.0001088909,0.00002862268,0.00005778908,0.997695,0.0001070536,0.0001007479,0.0008530526],"study_design_scores_gemma":[0.00003426449,0.0003699259,0.003143063,0.000002906302,0.00002481348,0.0004513568,0.0001175566,0.0007433125,0.9935147,0.00006345141,0.00153022,0.00000440867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995544,0.001381203,0.000756588,0.0001787775,0.00004615364,0.00001955107,0.0002385641,0.00007542466,0.001759784],"genre_scores_gemma":[0.9967281,0.0004528222,0.0002268567,0.00003122689,0.000009687627,0.00001039825,0.000241458,0.00001111035,0.002288283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002564759,"threshold_uncertainty_score":0.007671297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247155225117795,"score_gpt":0.2589116816467328,"score_spread":0.2364401293955549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}