{"id":"W2042912904","doi":"10.1038/jid.2008.207","title":"Arsenite Suppresses Notch1 Signaling in Human Keratinocytes","year":2008,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; U.S. Public Health Service; McGill University","keywords":"Arsenite; Cell biology; Keratinocyte; Carcinogenesis; Intracellular; Biology; Signal transduction; Mechanism of action; Cellular differentiation; Downregulation and upregulation; Receptor; Cancer research; Chemistry; Cell culture; Biochemistry; Arsenic; Gene; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154515,0.0001178446,0.0002271298,0.0001160697,0.0001203817,0.00000362944,0.0001225819,0.0001609835,0.00002105261],"category_scores_gemma":[0.0001219437,0.0001042673,0.00006369082,0.00008565884,0.0004465865,0.000009496867,0.00006258285,0.0001308425,0.000005440835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002285681,"about_ca_system_score_gemma":0.0001079768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002801836,"about_ca_topic_score_gemma":0.00002831905,"domain_scores_codex":[0.9990113,0.000175482,0.0004367021,0.0001349358,0.00007909538,0.0001624647],"domain_scores_gemma":[0.9994031,0.00003177695,0.0002901444,0.00008147562,0.000124157,0.0000693518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005102295,0.00002731611,0.06924029,0.000006812543,0.00004115584,0.0001328011,0.0002714727,0.000125412,0.9284113,0.00006708458,0.001599082,0.00002622712],"study_design_scores_gemma":[0.0005685783,0.0001150965,0.0544952,0.00001682012,0.000005650671,0.002764119,0.0000638928,0.000005450039,0.9393238,0.0005542379,0.001981436,0.0001056763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984801,0.0006122726,0.00005284983,0.0004196084,0.00009816367,0.00005511513,0.000002605425,0.000002582182,0.000276698],"genre_scores_gemma":[0.9976491,0.00006852886,0.001597045,0.0004050882,0.00008610955,0.000002889122,0.00004049412,0.000008012202,0.0001426959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01474509,"threshold_uncertainty_score":0.4251898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247155225117795,"score_gpt":0.2589116816467328,"score_spread":0.2364401293955549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}