{"id":"W2042950897","doi":"10.1016/j.jmb.2008.01.063","title":"Recognition of Non-canonical Peptides by the Yeast Fus1p SH3 Domain: Elucidation of a Common Mechanism for Diverse SH3 Domain Specificities","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"SH3 domain; Binding site; Binding selectivity; Biology; Binding domain; Plasma protein binding; Computational biology; Biochemistry; Chemistry; Biophysics; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002841823,0.000208691,0.0002109295,0.0001105337,0.0002219287,0.0004185181,0.0003322987,0.0003590038,0.0009028875],"category_scores_gemma":[0.000283442,0.0001507179,0.0003090956,0.00009663292,0.0002789688,0.0004743243,0.0004339679,0.0004853062,0.0003650752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002665442,"about_ca_system_score_gemma":0.000157877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003441832,"about_ca_topic_score_gemma":0.0004577363,"domain_scores_codex":[0.9998904,0.00001334591,0.000006986003,0.00002309477,0.00002889422,0.00003719057],"domain_scores_gemma":[0.9998199,0.00005800646,0.0000291424,0.00002518445,0.00002772034,0.00003996322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002092874,0.0000102443,0.0008196543,0.00003022184,0.000005036627,0.0001692303,0.00005316029,0.0001935769,0.9956157,0.0008554375,0.00005068364,0.001987866],"study_design_scores_gemma":[0.00003506188,0.000150536,0.01176391,0.000006991994,0.00001523175,0.001034084,0.0001482469,0.004826554,0.9795068,0.001028255,0.001467963,0.0000164625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935196,0.0003605275,0.005242507,0.00004565739,0.000007604653,0.000007733578,0.00005322614,0.00002281145,0.0007403251],"genre_scores_gemma":[0.9975566,0.0001224264,0.001647672,0.00004931316,0.000004468388,0.000007184618,0.0001050794,0.000007428464,0.0004997638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009028875,"threshold_uncertainty_score":0.003020465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044652650125169,"score_gpt":0.2595934196794863,"score_spread":0.2391468931782346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}