{"id":"W2042988852","doi":"10.1371/journal.pone.0100035","title":"Systemic Sclerosis Immunoglobulin Induces Growth and a Pro-Fibrotic State in Vascular Smooth Muscle Cells through the Epidermal Growth Factor Receptor","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Université de Montréal; McGill University; Jewish General Hospital","funders":"Actelion Pharmaceuticals; Canadian Institutes of Health Research; Dalhousie University; Canadian Arthritis Network; Arthritis Society; McGill University; Dr. Fooke Laboratorien; Pfizer; McMaster University; Jewish General Hospital; University of Ottawa","keywords":"Vascular smooth muscle; Platelet-derived growth factor receptor; Platelet-derived growth factor; Biology; Signal transduction; Immunoglobulin G; Epidermal growth factor receptor; Growth factor; Autoantibody; Fibrosis; Protein kinase B; Phosphorylation; Receptor; Antibody; Endocrinology; Cancer research; Immunology; Internal medicine; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738988,0.0003481949,0.000146855,0.0002206609,0.0000932516,0.0001196177,0.00005812446,0.0001979625,0.001821447],"category_scores_gemma":[0.000123471,0.00007498668,0.0002176241,0.0001115337,0.0001291234,0.00006512082,0.0001307153,0.0002647339,0.0002728303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221216,"about_ca_system_score_gemma":0.00009297697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002415,"about_ca_topic_score_gemma":0.0003933642,"domain_scores_codex":[0.9998227,0.00005351664,0.00001218466,0.00001853377,0.00004787964,0.00004523086],"domain_scores_gemma":[0.99991,0.00002398067,0.00001912357,0.00001087868,0.00001334555,0.00002268043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008032678,0.00003249531,0.0007952056,0.00003469697,0.000006327187,0.0001269577,0.00001171963,0.00001037292,0.9978934,0.00001677033,0.00002816392,0.0009636214],"study_design_scores_gemma":[0.0001110573,0.002344547,0.1108479,0.00003125073,0.00008260092,0.001661287,0.0001132975,0.0006918023,0.881025,0.00008005658,0.003006216,0.00000514296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974407,0.001010679,0.0003985905,0.00004915306,0.00001488867,0.000009522123,0.00004390729,0.00003434881,0.0009982804],"genre_scores_gemma":[0.9979955,0.0005283948,0.0003151897,0.00005258815,0.00002079591,0.00001513079,0.000132799,0.000005119601,0.0009344071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821447,"threshold_uncertainty_score":0.006093383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368659056950099,"score_gpt":0.2206002700651609,"score_spread":0.1769136794956599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}