{"id":"W2043009231","doi":"10.1038/mt.2011.54","title":"Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Small interfering RNA; Anaplastic lymphoma kinase; Neuroblastoma; Gene knockdown; Gene silencing; Cancer research; RNA interference; Tyrosine kinase; Molecular biology; Targeted therapy; Chemistry; Cell culture; Biology; RNA; Transfection; Cancer; Cell biology; Signal transduction; Medicine; Gene; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009138302,0.0002514027,0.0002762722,0.0001455965,0.00009469737,0.00003132734,0.0001699856,0.0000700098,0.0008663017],"category_scores_gemma":[0.0000371055,0.0002050412,0.0001938851,0.0003011279,0.0001106281,0.0000754769,0.00004152624,0.0002185469,0.0004644874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003721638,"about_ca_system_score_gemma":0.00007459964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002340069,"about_ca_topic_score_gemma":0.000002157773,"domain_scores_codex":[0.9981405,0.0001200988,0.0002596996,0.000435567,0.0004490766,0.0005950604],"domain_scores_gemma":[0.9989129,0.00002682204,0.00005651703,0.0005132321,0.00009399743,0.000396524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001079871,0.0008067829,0.001325398,0.000008702984,0.0002204587,0.002838217,0.000217015,0.000001196979,0.9697046,0.0002508023,0.0001832579,0.02336374],"study_design_scores_gemma":[0.003316209,0.001621465,0.04122592,0.00003047789,0.0000252969,0.0001443611,0.00002033248,0.00004616969,0.9471661,0.0002712527,0.005956634,0.0001757732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906543,0.0006363191,0.0002928622,0.0004127971,0.00008821376,0.0005725639,0.000003907871,0.0001841492,0.007154828],"genre_scores_gemma":[0.9967915,0.0002568432,0.001254043,0.00114685,0.00004629357,0.00004285051,0.000009803418,0.00006448779,0.0003872893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03990052,"threshold_uncertainty_score":0.9485396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04653958406937175,"score_gpt":0.266050676698893,"score_spread":0.2195110926295212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}