{"id":"W2043032580","doi":"10.1038/ja.2011.113","title":"Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci","year":2011,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Kane Biotech (Canada)","funders":"U.S. Department of State; US-UK Fulbright Commission; Genentech; University of Manitoba; National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council","keywords":"Biofilm; Microbiology; Staphylococcus aureus; Staphylococcus epidermidis; Antimicrobial; Tobramycin; Antibiotics; Crystal violet; Chemistry; Pseudomonas aeruginosa; Bacteria; Biology; Gentamicin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006390551,0.0001392779,0.0002115735,0.00006479197,0.00009359338,0.00002176346,0.0001647563,0.0001068293,0.00001370291],"category_scores_gemma":[0.0001028334,0.00009448497,0.0000733046,0.00007685107,0.00021994,0.000009296265,0.0001062086,0.0001404942,8.825067e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009389991,"about_ca_system_score_gemma":0.00006191141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003556234,"about_ca_topic_score_gemma":0.0003821072,"domain_scores_codex":[0.9990343,0.0001688089,0.000391223,0.0001264948,0.00007437793,0.0002047725],"domain_scores_gemma":[0.9993135,0.00002071407,0.0002555952,0.0002220381,0.0001000974,0.00008808944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003458564,0.0002347943,0.05280842,0.00001584806,0.00002858186,0.00001769768,0.00008619078,7.361175e-7,0.9458641,0.00003426776,0.0002567044,0.0003068143],"study_design_scores_gemma":[0.0006544135,0.0007248346,0.1119309,0.00007463483,0.00004642636,0.0002166129,0.00015805,0.000002591131,0.8857607,0.00004619248,0.0002498066,0.0001349085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993709,0.0001802871,0.00001165109,0.00005129117,0.0001566355,0.00008698215,0.000008376598,0.000002667902,0.0001312318],"genre_scores_gemma":[0.998276,0.0006509956,0.0007711949,0.0001286996,0.0001340267,4.6389e-9,0.000007069191,0.00001358892,0.00001841281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06010341,"threshold_uncertainty_score":0.3852985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907688501045014,"score_gpt":0.2401515697034615,"score_spread":0.2210746846930114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}