{"id":"W2043032580","doi":"10.1038/ja.2011.113","title":"Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci","year":2011,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Kane Biotech (Canada)","funders":"U.S. Department of State; US-UK Fulbright Commission; Genentech; University of Manitoba; National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council","keywords":"Biofilm; Microbiology; Staphylococcus aureus; Staphylococcus epidermidis; Antimicrobial; Tobramycin; Antibiotics; Crystal violet; Chemistry; Pseudomonas aeruginosa; Bacteria; Biology; Gentamicin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003198256,0.0003845123,0.0003695266,0.0002220017,0.00007799373,0.0003080812,0.0002270609,0.0003795148,0.001556206],"category_scores_gemma":[0.0004771886,0.0002317019,0.0002638383,0.0001130652,0.0003502818,0.0001589975,0.0002330832,0.0006645999,0.0003743075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003013573,"about_ca_system_score_gemma":0.0002725332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007297926,"about_ca_topic_score_gemma":0.0007925443,"domain_scores_codex":[0.9997519,0.00006751008,0.00002749495,0.00004057117,0.00005797536,0.00005465725],"domain_scores_gemma":[0.9996411,0.0001297608,0.00008021302,0.00004917325,0.00002435293,0.0000755153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001941216,0.00003727034,0.0001179029,0.00001398842,0.000003877601,0.0000140764,0.000005726379,0.0000267173,0.9990809,0.00002002228,0.00002911414,0.000456216],"study_design_scores_gemma":[0.00003634356,0.0006607756,0.002428405,0.000005189173,0.000009232193,0.0001787329,0.00002359903,0.0004618054,0.995742,0.00003227405,0.0004178052,0.0000036974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995645,0.001799102,0.001625212,0.0001712695,0.00004971295,0.00001300517,0.0001667061,0.00005739633,0.0004725877],"genre_scores_gemma":[0.9952871,0.0006197935,0.00182739,0.00007520045,0.00001975818,0.00001826677,0.000367583,0.00001954017,0.00176539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001556206,"threshold_uncertainty_score":0.005206048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907688501045014,"score_gpt":0.2401515697034615,"score_spread":0.2210746846930114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}