{"id":"W2043039532","doi":"10.1634/stemcells.2007-0255","title":"Concise Review: Role and Function of the Ubiquitin-Proteasome System in Mammalian Stem and Progenitor Cells","year":2007,"lang":"en","type":"review","venue":"Stem Cells","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Stem Cell Network","keywords":"Biology; Proteasome; Ubiquitin; Cell biology; Progenitor cell; Stem cell; Protein degradation; Deubiquitinating enzyme; Embryonic stem cell; Ubiquitin ligase; Haematopoiesis; Homing (biology); Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005585236,0.001303548,0.001501359,0.001872954,0.000326433,0.001005556,0.001219564,0.001429918,0.003365437],"category_scores_gemma":[0.000737735,0.0002376058,0.000368584,0.002365751,0.0004732194,0.001589666,0.0005819338,0.001578204,0.0042218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005762906,"about_ca_system_score_gemma":0.0009687606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005941888,"about_ca_topic_score_gemma":0.0009766676,"domain_scores_codex":[0.9997908,0.00003354386,0.00003063945,0.00002775005,0.0001020077,0.00001522043],"domain_scores_gemma":[0.9996929,0.00008974075,0.00003853637,0.000009246223,0.0001174744,0.00005216965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001201953,0.00007108994,0.0001201087,0.01052626,0.00006889932,0.0005773514,0.00004803965,0.0003060777,0.002625588,0.002337299,0.2072891,0.77591],"study_design_scores_gemma":[0.00002086509,0.00004960108,0.0002891645,0.001029033,0.00004940021,0.001611849,0.00002219605,0.0000529762,0.0003971636,0.0007869075,0.9956788,0.0000120071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001083233,0.9952086,0.0002644692,0.0005937177,0.00259031,0.000009945096,0.0000243824,0.00001405574,0.001186171],"genre_scores_gemma":[0.0005067058,0.9952798,0.0004113804,0.0005394488,0.001634643,0.00001247048,0.00005914809,0.000002724294,0.001553646],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003365437,"threshold_uncertainty_score":0.01125848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357657860174904,"score_gpt":0.2625344644676927,"score_spread":0.2389578858659437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}