{"id":"W2043087478","doi":"10.1016/j.bbapap.2007.11.012","title":"1.2Å-resolution crystal structures reveal the second tetrahedral intermediates of streptogrisin B (SGPB)","year":2007,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Tetrahedral carbonyl addition compound; Chemistry; Crystallography; Molecule; Tetrapeptide; Tetrahedron; Stereochemistry; Carboxylate; Residue (chemistry); Active site; Crystal structure; Hydrolase; Protein structure; Catalysis; Enzyme; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004705169,0.0003230004,0.0004683584,0.0002027957,0.0001860464,0.00006931301,0.0001781001,0.0002060294,0.000123436],"category_scores_gemma":[0.00008884625,0.0002202703,0.0002685676,0.0003565721,0.000500003,0.0001447491,0.0001238019,0.0004764899,0.000003948992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004895578,"about_ca_system_score_gemma":0.0001218169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008476178,"about_ca_topic_score_gemma":0.00009599739,"domain_scores_codex":[0.9981189,0.00009333998,0.0006026824,0.0004300979,0.0003567307,0.0003982394],"domain_scores_gemma":[0.9987559,0.00007885052,0.0003868858,0.000437702,0.0001457577,0.0001949286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000486006,0.0001740414,0.0001028773,0.0002040723,0.0001485193,0.000007271372,0.0004987292,6.362898e-7,0.9968277,0.0004290959,0.000351942,0.0007691309],"study_design_scores_gemma":[0.001067056,0.0005599502,0.02411252,0.0002706672,0.0001130007,0.0000398651,0.0003598956,0.0001598553,0.9718959,0.0008870002,0.0002770531,0.0002572248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953712,0.00007207742,0.0004191666,0.002127238,0.00004018451,0.001228642,0.0002187277,0.00006127716,0.0004614555],"genre_scores_gemma":[0.994398,0.00003451555,0.00419317,0.0004932509,0.0003813674,0.00003862115,0.000123806,0.00003507254,0.0003022184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02493177,"threshold_uncertainty_score":0.8982362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075733613429501,"score_gpt":0.2603112844220682,"score_spread":0.2495539482877732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}