{"id":"W2043179736","doi":"10.1016/j.drudis.2009.06.007","title":"FN3: a new protein scaffold reaches the clinic","year":2009,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Affinities; Computational biology; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007843668,0.0006929167,0.002196865,0.0001938699,0.0002042912,0.0001953219,0.0007327924,0.0003225897,0.0006809537],"category_scores_gemma":[0.0001946557,0.0003467165,0.001573793,0.0005179654,0.0002257256,0.0001872479,0.0002705575,0.001302724,0.002025232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388404,"about_ca_system_score_gemma":0.001822271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004010176,"about_ca_topic_score_gemma":0.00004575811,"domain_scores_codex":[0.9962752,0.0003819357,0.0009339442,0.0007467501,0.0009230907,0.0007390882],"domain_scores_gemma":[0.997693,0.0004599585,0.0003333174,0.00108956,0.00005360847,0.0003705343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001014127,0.0001642444,0.000009649692,0.005661919,0.0003088423,0.0001340354,0.00007838253,5.113345e-8,0.00000228244,0.0007002158,0.1078576,0.8849814],"study_design_scores_gemma":[0.0003033382,0.0001853383,0.00003891754,0.01745163,0.0006940911,0.0001521838,0.00002529999,0.000001072415,0.00001159412,0.0005927926,0.9801618,0.0003819558],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001077044,0.9663128,0.000005175968,0.004533143,0.0002031303,0.00255208,0.00008953569,0.000066459,0.02612998],"genre_scores_gemma":[0.00001342529,0.6430584,0.00007990693,0.0004322685,0.001388366,0.00009640127,0.0002445572,0.00005644399,0.3546302],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8845994,"threshold_uncertainty_score":0.9998985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0797466542329868,"score_gpt":0.3833946429457091,"score_spread":0.3036479887127222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}