{"id":"W2043203105","doi":"10.1074/jbc.m800209200","title":"Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Howard Hughes Medical Institute","keywords":"Signal transduction; Tyrosine phosphorylation; Phosphorylation; Biology; Immunoreceptor tyrosine-based activation motif; Autoimmunity; Systemic lupus erythematosus; Cell biology; Receptor; Tyrosine; Signal transducing adaptor protein; T-cell receptor; SH2 domain; Immunology; Immune system; T cell; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004233554,0.0001533253,0.0004453562,0.00008689189,0.00005681174,0.000004701132,0.000187474,0.0004079643,0.0005186271],"category_scores_gemma":[0.0003090615,0.0001250314,0.0001512574,0.0002150535,0.0001590392,0.0001106318,0.00002443066,0.0004938493,0.00001440899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004684189,"about_ca_system_score_gemma":0.0001839333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009945167,"about_ca_topic_score_gemma":1.086907e-7,"domain_scores_codex":[0.9985057,0.0002087045,0.0008501761,0.0001500412,0.0000510807,0.0002343003],"domain_scores_gemma":[0.9988441,0.0002516071,0.0006021219,0.0001126422,0.0001660811,0.00002345317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001324103,0.0002424692,0.001459621,0.00001565705,0.00005683476,0.000007479715,0.0000720842,0.000193857,0.9956789,0.000001425685,0.0006031115,0.0003444516],"study_design_scores_gemma":[0.00390554,0.0002097955,0.001530735,0.0001273125,0.000008988708,0.0002107043,0.0002440191,0.00004770273,0.9911959,0.00001339852,0.002382472,0.0001234675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955438,0.003235287,0.0005701687,0.0000732425,0.0002649382,0.00007616041,0.000005028718,0.00001289429,0.0002184362],"genre_scores_gemma":[0.9991105,0.0003725589,0.00003758198,0.0001432331,0.0000243808,0.000004685415,0.00004711784,0.00000766733,0.0002523086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004483042,"threshold_uncertainty_score":0.5678604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966894143849131,"score_gpt":0.2294303713002897,"score_spread":0.2097614298617984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}