{"id":"W2043203105","doi":"10.1074/jbc.m800209200","title":"Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Howard Hughes Medical Institute","keywords":"Signal transduction; Tyrosine phosphorylation; Phosphorylation; Biology; Immunoreceptor tyrosine-based activation motif; Autoimmunity; Systemic lupus erythematosus; Cell biology; Receptor; Tyrosine; Signal transducing adaptor protein; T-cell receptor; SH2 domain; Immunology; Immune system; T cell; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009452488,0.0002363611,0.0001603093,0.0001379621,0.0001092751,0.0002549162,0.0001433688,0.0002321118,0.0004640803],"category_scores_gemma":[0.0001324636,0.00005635915,0.000136516,0.0000796329,0.0001928822,0.0001704102,0.0001716219,0.000367048,0.0001969635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123293,"about_ca_system_score_gemma":0.0001063914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002179177,"about_ca_topic_score_gemma":0.0002600054,"domain_scores_codex":[0.9998806,0.0000314901,0.000009425306,0.00002110739,0.00002372393,0.00003367506],"domain_scores_gemma":[0.9999048,0.00001956194,0.00002995991,0.00001082827,0.000007924707,0.00002711647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003728576,0.000004152854,0.0001120318,0.000008322029,6.343597e-7,0.00003115163,0.000005909182,0.00002206356,0.9992901,0.00004692251,0.000006295267,0.0004350944],"study_design_scores_gemma":[0.00001853628,0.0002535172,0.004368317,0.000004058106,0.000006477665,0.0003261862,0.00002563462,0.001482669,0.992251,0.0000672492,0.001192704,0.000003611279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949007,0.001401125,0.002696133,0.00004378391,0.000009380179,0.00001511412,0.00007691765,0.00005767979,0.0007991403],"genre_scores_gemma":[0.9975469,0.0004510126,0.001242766,0.00001418359,0.000006367585,0.00001566902,0.00007468586,0.000005782584,0.0006426775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004640803,"threshold_uncertainty_score":0.001552522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966894143849131,"score_gpt":0.2294303713002897,"score_spread":0.2097614298617984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}