{"id":"W2043235107","doi":"10.1002/humu.20827","title":"Glial Cells Missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism","year":2008,"lang":"en","type":"article","venue":"Human Mutation","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Biology; Hypoparathyroidism; Transactivation; Calcium-sensing receptor; Mutant; Transcription factor; Wild type; Transfection; Endocrinology; Parathyroid gland; Gene; Mutation; Parathyroid chief cell; Internal medicine; Parathyroid hormone; Cell biology; Genetics; Calcium; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784666,0.001111951,0.0004540163,0.0004408762,0.0002603458,0.0002765004,0.000458551,0.0006515578,0.001823027],"category_scores_gemma":[0.000234753,0.0002934316,0.0005275777,0.0002161494,0.0004401852,0.0001032263,0.0003311463,0.0007488318,0.0004684678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000484266,"about_ca_system_score_gemma":0.0003759393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002320645,"about_ca_topic_score_gemma":0.002572219,"domain_scores_codex":[0.9997209,0.00004663636,0.00003577487,0.00006317052,0.00009354348,0.00003994676],"domain_scores_gemma":[0.9997075,0.00007367324,0.00006734428,0.00002200287,0.00001425911,0.0001151453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008461477,0.00003130084,0.0001003233,0.00001771463,0.000006570912,0.0005299273,0.00001789228,0.00004179832,0.9988512,0.00005281606,0.00003029777,0.0002355558],"study_design_scores_gemma":[0.0001020422,0.0003670326,0.003161837,0.000009804221,0.00004115342,0.005483908,0.00005044959,0.002362626,0.9859492,0.00004816473,0.002410476,0.00001337512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968353,0.0005301636,0.001268695,0.0001202156,0.00004557119,0.0000250345,0.0003337205,0.0001580429,0.0006832995],"genre_scores_gemma":[0.9942582,0.00040473,0.002206919,0.00006211272,0.00001632333,0.00003236819,0.0003895115,0.00008378889,0.00254605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002320645,"threshold_uncertainty_score":0.006098688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915650776285529,"score_gpt":0.2711788655704594,"score_spread":0.2520223578076042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}