{"id":"W2043235107","doi":"10.1002/humu.20827","title":"Glial Cells Missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism","year":2008,"lang":"en","type":"article","venue":"Human Mutation","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Biology; Hypoparathyroidism; Transactivation; Calcium-sensing receptor; Mutant; Transcription factor; Wild type; Transfection; Endocrinology; Parathyroid gland; Gene; Mutation; Parathyroid chief cell; Internal medicine; Parathyroid hormone; Cell biology; Genetics; Calcium; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002570687,0.0003545338,0.0006162569,0.0001122759,0.0005638982,0.00002315617,0.00008063894,0.0001430223,0.00001354052],"category_scores_gemma":[0.0001219145,0.0002144352,0.0001786267,0.000287868,0.0003666218,0.0001302475,0.000009851771,0.0002236008,0.00002079331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757957,"about_ca_system_score_gemma":0.0001512862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002667553,"about_ca_topic_score_gemma":0.00004034015,"domain_scores_codex":[0.9980189,0.000307218,0.0004444802,0.0003838795,0.0004819334,0.0003635661],"domain_scores_gemma":[0.998661,0.000412836,0.0003911723,0.0002572068,0.0001661152,0.0001117157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002168787,0.0004488728,0.001145877,0.00001633384,0.0003868,0.000386789,0.006757103,0.00009254085,0.9876581,0.00001107964,0.0004356036,0.0004920803],"study_design_scores_gemma":[0.01245934,0.002746375,0.02439925,0.00008966291,0.0005282385,0.0001723932,0.0002594763,0.0009999661,0.9580068,0.00008279088,0.00001864366,0.0002370814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966084,0.0006295068,0.001009587,0.0001141302,0.0001024333,0.001143305,0.00003800253,0.00004480378,0.0003098778],"genre_scores_gemma":[0.998985,0.00002481874,0.0004252955,0.00003728976,0.00006893752,0.00003368951,0.0001064101,0.00004793729,0.0002706336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02965135,"threshold_uncertainty_score":0.8744416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915650776285529,"score_gpt":0.2711788655704594,"score_spread":0.2520223578076042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}