{"id":"W2043255932","doi":"10.3109/10253890.2013.850669","title":"Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia","year":2013,"lang":"en","type":"article","venue":"Stress","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Nucleus accumbens; Endocrinology; Internal medicine; Anhedonia; Population; Habituation; Neuropeptide; Enkephalin; Corticosterone; Downregulation and upregulation; Psychology; Neuroscience; Chemistry; Medicine; Dopamine; Biochemistry; Hormone; Opioid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000543676,0.000301963,0.0002604766,0.0001814247,0.0001121879,0.0001402685,0.0001155475,0.0001650777,0.0006955506],"category_scores_gemma":[0.00007780445,0.0001192965,0.0001679692,0.00009311769,0.0002795156,0.0001264798,0.0001652699,0.000419409,0.0001030766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097583,"about_ca_system_score_gemma":0.0001597994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009366018,"about_ca_topic_score_gemma":0.002993256,"domain_scores_codex":[0.9999568,0.000003918918,0.000005656594,0.00001250247,0.000009210306,0.00001199803],"domain_scores_gemma":[0.999872,0.000007565426,0.0000601247,0.00001095742,0.00001038524,0.00003904926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001552762,0.00002920198,0.001883332,0.00002430092,0.00001426818,0.0001469289,0.00001721567,0.0000161257,0.9970573,0.0000164702,0.00001371841,0.0006259566],"study_design_scores_gemma":[0.00003256223,0.001172792,0.7525761,0.00002122576,0.00007468063,0.001710134,0.000210144,0.0006674664,0.2427104,0.0001842613,0.0006252986,0.00001501015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990552,0.0003360969,0.0003079399,0.00002142114,0.000005155862,0.000005954248,0.0001208264,0.000009305101,0.0001381779],"genre_scores_gemma":[0.9984689,0.0005024849,0.0003250725,0.00002885386,0.000006431796,0.0000173181,0.000172981,0.000003984519,0.000474016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009366018,"threshold_uncertainty_score":0.002326846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04360827742508792,"score_gpt":0.2944340064576979,"score_spread":0.25082572903261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}